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    nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [ Danio rerio (zebrafish) ]

    Gene ID: 323099, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nfkbiabprovided by ZNC
    Official Full Name
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1819
    See related
    Ensembl:ENSDARG00000007693 AllianceGenome:ZFIN:ZDB-GENE-030131-1819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ikbaB; NFKBIA; zgc:56666; zgc:77616; wu:fb81f08
    Summary
    Predicted to enable NF-kappaB binding activity and protein sequestering activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Predicted to be active in cytosol. Is expressed in EVL; epidermis; lateral line system; vent; and ventricular zone. Human ortholog(s) of this gene implicated in several diseases, including childhood-onset asthma; ectodermal dysplasia and immunodeficiency 2; hematologic cancer (multiple); hepatitis B; and lung disease (multiple). Orthologous to human NFKBIA (NFKB inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nfkbiab in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (12942665..12946736)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (12788599..12792670)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene Ral GTPase activating protein catalytic subunit alpha 1 Neighboring gene INSM transcriptional repressor 2 Neighboring gene proteasome 20S subunit alpha 6a Neighboring gene protein only RNase P catalytic subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of two types of IκBα orthologues in orange-spotted grouper, Epinephelus coioides. Gao R, et al. Fish Shellfish Immunol, 2014 May. PMID 24594011
    2. Melatonin receptor agonist Piper betle L. ameliorates dexamethasone-induced early life stress in adult zebrafish. Kumari Y, et al. Exp Ther Med, 2019 Aug. PMID 31363378, Free PMC Article
    3. A high-sensitivity bi-directional reporter to monitor NF-κB activity in cell culture and zebrafish in real time. Kuri P, et al. J Cell Sci, 2017 Feb 1. PMID 27980067
    4. NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration. Mishra R, et al. Dev Cell, 2020 Jan 27. PMID 31866203
    5. Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS. Hiolski EM, et al. Aquat Toxicol, 2014 Oct. PMID 25033243, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56666

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein sequestering activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b
    Names
    NF-kappaB inhibitor alpha-like protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199629.1 → NP_955923.1  nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b

      See identical proteins and their annotated locations for NP_955923.1

      Status: PROVISIONAL

      Source sequence(s)
      BC050175
      UniProtKB/TrEMBL
      F6NWV1, Q6P610, Q7ZW68
      Related
      ENSDARP00000015303.5, ENSDART00000016597.6
      Conserved Domains (4) summary
      cd00204
      Location:103 → 234
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:113 → 241
      Ank_2; Ankyrin repeats (3 copies)
      pfam13857
      Location:167 → 221
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:110 → 139
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      12942665..12946736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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