ddx6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx6provided by ZNC
Official Full Name: DEAD (Asp-Glu-Ala-Asp) box helicase 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-83
See related: Ensembl:ENSDARG00000061338 AllianceGenome:ZFIN:ZDB-GENE-070912-83
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p54a; si:ch211-147p17.1
Summary: Predicted to enable mRNA binding activity. Acts upstream of or within response to heat and stress granule assembly. Located in cytoplasmic ribonucleoprotein granule. Orthologous to human DDX6 (DEAD-box helicase 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (43868341..43884017, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (43873731..43890597, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fc35e02.x1 (e-PCR)
- UniSTS:193632

fi84e11.y1 (e-PCR)
- UniSTS:198099

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in P-body assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stress granule assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within stress granule assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stress granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX6

Names: DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

XP_684923.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

43868341..43884017 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_679831.10 → XP_684923.1 probable ATP-dependent RNA helicase DDX6

UniProtKB/TrEMBL

A0A8N7UUZ0, E7FD91

Related

ENSDARP00000081816.5, ENSDART00000087382.7

Conserved Domains (3) summary

PTZ00424
Location:99 → 474

PTZ00424; helicase 45; Provisional

cd00079
Location:312 → 438

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:99 → 300

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...