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    ap3b1a adaptor related protein complex 3 subunit beta 1a [ Danio rerio (zebrafish) ]

    Gene ID: 563316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ap3b1aprovided by ZNC
    Official Full Name
    adaptor related protein complex 3 subunit beta 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031112-8
    See related
    AllianceGenome:ZFIN:ZDB-GENE-031112-8
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    ap3b1; cb964
    Summary
    Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of AP-3 adaptor complex and clathrin adaptor complex. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; optic vesicle; ventral mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome; Hermansky-Pudlak syndrome 2; interstitial lung disease; neutropenia; and pulmonary fibrosis. Orthologous to human AP3B1 (adaptor related protein complex 3 subunit beta 1). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See ap3b1a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (7298573..7440389)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (6483810..6601285, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) Neighboring gene EGF-like-domain, multiple 7 Neighboring gene microRNA mir-126b Neighboring gene uncharacterized LOC110438212 Neighboring gene uncharacterized LOC137488780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization and in vivo image analysis of novel zebrafish Danio rerio pigment mutants. Hsu CC, et al. J Fish Biol, 2013 May. PMID 23639161
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit beta-1
    Names
    adaptor related protein complex 3 beta 1 subunit
    adaptor-related protein complex 3, beta 1 subunit a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      7298573..7440389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469001.2 → XP_021324676.1  AP-3 complex subunit beta-1

      UniProtKB/TrEMBL
      A0A8M9PQW2
      Conserved Domains (3) summary
      sd00044
      Location:124 → 152
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:54 → 587
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:832 → 974
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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