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    abraxas2 abraxas 2, BRISC complex subunit [ Danio rerio (zebrafish) ]

    Gene ID: 406584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abraxas2provided by ZNC
    Official Full Name
    abraxas 2, BRISC complex subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2491
    See related
    Ensembl:ENSDARG00000098907 AllianceGenome:ZFIN:ZDB-GENE-040426-2491
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fam175b; abraxas2b; zgc:85800; wu:fi33f11
    Summary
    Predicted to enable microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and mitotic spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm; microtubule; and spindle pole. Predicted to be active in nucleus. Orthologous to human ABRAXAS2 (abraxas 2, BRISC complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See abraxas2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (31805576..31819832, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (31788601..31802863, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108179780 Neighboring gene nucleotide binding protein-like Neighboring gene D-aminoacyl-tRNA deacylase 2 Neighboring gene Rho GTPase activating protein 5 Neighboring gene EEF1A lysine methyltransferase 2 Neighboring gene inhibitory synaptic factor 2Ab Neighboring gene uncharacterized LOC103909048

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Prendergast AE, et al. Curr Biol, 2023 Mar 13. PMID 36791723
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BRISC complex subunit Abraxas 2
    Names
    BRISC complex subunit abraxas 2
    abraxas 2b, BRISC complex subunit
    family with sequence similarity 175, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213295.1 → NP_998460.1  BRISC complex subunit Abraxas 2

      See identical proteins and their annotated locations for NP_998460.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067636
      UniProtKB/TrEMBL
      Q6NWD2
      Conserved Domains (1) summary
      pfam07194
      Location:92 → 165
      P2; P2 response regulator binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      31805576..31819832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214379.1 → XP_068070480.1  BRISC complex subunit Abraxas 2 isoform X1

      UniProtKB/Swiss-Prot
      A0A8M3AJY3, A0A8M3AUE4, Q6NWD2
      UniProtKB/TrEMBL
      A0A9U6SKU9

    2. XM_009293129.4 → XP_009291404.1  BRISC complex subunit Abraxas 2 isoform X1

      UniProtKB/Swiss-Prot
      A0A8M3AJY3, A0A8M3AUE4, Q6NWD2
      UniProtKB/TrEMBL
      A0A9U6SKU9
      Related
      ENSDARP00000136248.1, ENSDART00000160281.2
      Conserved Domains (2) summary
      pfam07194
      Location:197 → 270
      P2; P2 response regulator binding domain
      pfam11825
      Location:278 → 352
      Nuc_recep-AF1; Nuclear/hormone receptor activator site AF-1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A8M3AJY3.1 GenPept UniProtKB/Swiss-Prot:A0A8M3AJY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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