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    ca9 carbonic anhydrase IX [ Danio rerio (zebrafish) ]

    Gene ID: 566612, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ca9provided by ZNC
    Official Full Name
    carbonic anhydrase IXprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080818-5
    See related
    Ensembl:ENSDARG00000102300 AllianceGenome:ZFIN:ZDB-GENE-080818-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb77; sb:cb77
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; brain; digestive system; forerunner cell group; and renal system. Human ortholog(s) of this gene implicated in hepatitis B; lung non-small cell carcinoma; and renal cell carcinoma. Orthologous to human CA9 (carbonic anhydrase 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ca9 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (6417327..6454397, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (6414369..6453213, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene tropomyosin 2 (beta) Neighboring gene zgc:114200 Neighboring gene decapping mRNA 2 Neighboring gene receptor accessory protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fluorinated benzenesulfonamide anticancer inhibitors of carbonic anhydrase IX exhibit lower toxic effects on zebrafish embryonic development than ethoxzolamide. Kazokaitė J, et al. Drug Chem Toxicol, 2017 Jul. PMID 27600313
    2. Identification and characterization of a novel zebrafish (Danio rerio) pentraxin-carbonic anhydrase. Patrikainen MS, et al. PeerJ, 2017. PMID 29230365, Free PMC Article
    3. Identification and expression of a novel carbonic anhydrase isozyme in the pufferfish Takifugu vermicularis. Sumi KR, et al. Gene, 2016 Aug 22. PMID 27188255
    4. Hypoxia-inducible carbonic anhydrase IX expression is insufficient to alleviate intracellular metabolic acidosis in the muscle of zebrafish, Danio rerio. Esbaugh AJ, et al. Am J Physiol Regul Integr Comp Physiol, 2009 Jan. PMID 18945954
    5. Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Sundaramurthi H, et al. Front Cell Dev Biol, 2020. PMID 32984302, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 9; carbonic anhydrase 14
    XP_694982.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      6417327..6454397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689890.9 → XP_694982.3  carbonic anhydrase 14

      UniProtKB/TrEMBL
      A0A8M3B325, A0A8N7TDP2
      Related
      ENSDARP00000134317.1, ENSDART00000168549.2
      Conserved Domains (1) summary
      cd03150
      Location:48 → 294
      alpha_CA_IX; Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed ...
    Nucleotide Protein Strain
    Heading Accession and Version

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