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    ap2m1a adaptor related protein complex 2 subunit mu 1a [ Danio rerio (zebrafish) ]

    Gene ID: 321051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ap2m1aprovided by ZNC
    Official Full Name
    adaptor related protein complex 2 subunit mu 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9784
    See related
    Ensembl:ENSDARG00000002790 AllianceGenome:ZFIN:ZDB-GENE-030131-9784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb34; Ap2m1; dpy-23; sb:cb34; zgc:55711; zgc:85653; wu:fa97a10
    Summary
    Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Is expressed in blood; mesoderm; notochord; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ap2m1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (9789820..9818673, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (9992000..10020853, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:ch1073-170o4.1 Neighboring gene small nucleolar RNA SNORA13 Neighboring gene phosphate cytidylyltransferase 1A, choline a Neighboring gene annexin A13, like Neighboring gene si:ch211-252f13.5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Gong Y, et al. Dev Comp Immunol, 2021 Aug. PMID 33848529
    2. In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. Hagemann AI, et al. J Cell Sci, 2014 Sep 15. PMID 25074807, Free PMC Article
    3. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
      Title: Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-2 adaptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-2 complex subunit mu-A
    Names
    AP-2 complex subunit mu-1-A
    AP-2 mu-2 chain A
    AP-2 mu-A chain
    adaptor protein complex AP-2, mu1
    adaptor-related protein complex 2, mu 1 subunit, a
    clathrin assembly protein complex 2 medium chain A
    clathrin assembly protein complex 2 mu-A medium chain
    clathrin coat assembly protein AP50-A
    clathrin coat-associated protein AP50-A
    mu2-adaptin-A
    plasma membrane adaptor AP-2 50 kDa protein A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291355.1 → NP_001278284.1  AP-2 complex subunit mu-A isoform 1

      See identical proteins and their annotated locations for NP_001278284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BX470264, EB766597, EH432280, EH456153
      UniProtKB/TrEMBL
      A0A8M1P618, A0A8M2B673, F1Q9V1, F1RD00
      Related
      ENSDARP00000106819.2, ENSDART00000124051.3
      Conserved Domains (1) summary
      cd09251
      Location:168 → 440
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

    2. NM_212577.2 → NP_997742.1  AP-2 complex subunit mu-A isoform 2

      See identical proteins and their annotated locations for NP_997742.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX470264, EB766597, EH432280, EH494715
      UniProtKB/Swiss-Prot
      Q6NWK2, Q802V9
      UniProtKB/TrEMBL
      A0A8M2B673, F1RD00
      Related
      ENSDARP00000046586.5, ENSDART00000046587.7
      Conserved Domains (2) summary
      cd09251
      Location:168 → 435
      AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
      cd14836
      Location:1 → 139
      AP2_Mu_N; AP-2 complex subunit mu N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      9789820..9818673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NWK2.1 GenPept UniProtKB/Swiss-Prot:Q6NWK2

    Gene LinkOut

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