pcca propionyl-CoA carboxylase subunit alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pccaprovided by ZNC
Official Full Name: propionyl-CoA carboxylase subunit alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-246
See related: Ensembl:ENSDARG00000028982 AllianceGenome:ZFIN:ZDB-GENE-040718-246
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb92g02; wu:fb92g02; zgc:100925
Summary: Predicted to enable propionyl-CoA carboxylase activity. Predicted to act upstream of or within lipid catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; immature eye; liver; optic tectum; and segmental plate. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCA (propionyl-CoA carboxylase subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (29862085..29953746)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (29058154..29149815)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables propionyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: propionyl-CoA carboxylase alpha chain, mitochondrial

Names: propionyl CoA carboxylase, alpha polypeptide; propionyl-Coenzyme A carboxylase, alpha polypeptide

NP_001002746.1

EC 6.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002746.2 → NP_001002746.1 propionyl-CoA carboxylase alpha chain, mitochondrial

See identical proteins and their annotated locations for NP_001002746.1

Status: PROVISIONAL

Source sequence(s)

BC076408

UniProtKB/TrEMBL

Q6DGE2

Related

ENSDARP00000117212.1, ENSDART00000133905.3

Conserved Domains (5) summary

cd06850
Location:643 → 708

biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...

smart00878
Location:378 → 485

Biotin_carb_C; Biotin carboxylase C-terminal domain

COG4770
Location:44 → 709

PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]

pfam00289
Location:44 → 152

CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain

pfam02786
Location:157 → 363

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain