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    atn1 atrophin 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    atn1provided by ZNC
    Official Full Name
    atrophin 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-426
    See related
    Ensembl:ENSDARG00000092067 AllianceGenome:ZFIN:ZDB-GENE-030131-426
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb30f09; wu:fb30f09; si:ch211-57k11.4
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in dentatorubral-pallidoluysian atrophy and schizophrenia. Orthologous to human ATN1 (atrophin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See atn1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (31846402..31868985)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (31890782..31912885)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene cell division cycle 42, like Neighboring gene myeloid leukemia factor 2 Neighboring gene uncharacterized LOC110437989 Neighboring gene uncharacterized LOC137487922 Neighboring gene RNA binding fox-1 homolog 1, like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Kossack ME, et al. Genetics, 2019 Jan. PMID 30446521, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    atrophin 1; atrophin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      31846402..31868985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158189.5 → XP_005158246.1  atrophin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B534, A0A8M9PK47, F6PDP0
      Related
      ENSDARP00000116176.2, ENSDART00000133886.3
      Conserved Domains (1) summary
      pfam03154
      Location:591 → 1182
      Atrophin-1; Atrophin-1 family

    2. XM_005158191.5 → XP_005158248.1  atrophin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M2B521, A0A8M9PK47
      Conserved Domains (1) summary
      pfam03154
      Location:591 → 1182
      Atrophin-1; Atrophin-1 family

    3. XM_017351523.3 → XP_017207012.1  atrophin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M6YVF4, A0A8M9PK47

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394963.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      109836..131511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473001.2 → XP_021328676.1  atrophin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PNR2, A0A8M9Q1Y5
      Conserved Domains (1) summary
      cl26464
      Location:1516 → 1664
      Atrophin-1; Atrophin-1 family

    2. XM_021473004.2 → XP_021328679.1  atrophin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PNR2, A0A8M9PUX1
      Conserved Domains (1) summary
      cl26464
      Location:836 → 1182
      Atrophin-1; Atrophin-1 family

    3. XM_021473002.2 → XP_021328677.1  atrophin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PC61, A0A8M9PNR2
      Conserved Domains (1) summary
      cl26464
      Location:1515 → 1663
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version

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