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    wrap53 WD repeat containing, antisense to TP53 [ Danio rerio (zebrafish) ]

    Gene ID: 321796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    wrap53provided by ZNC
    Official Full Name
    WD repeat containing, antisense to TP53provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-515
    See related
    Ensembl:ENSDARG00000086150 AllianceGenome:ZFIN:ZDB-GENE-030131-515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb34f12; fi26g08; wu:fb34f12; wu:fi26g08
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in Cajal body organization. Predicted to be active in Cajal body. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See wrap53 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (20917964..20940213)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (20651599..20673875)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene GRB10 interacting GYF protein 1a Neighboring gene uncharacterized LOC137496164 Neighboring gene si:dkey-111f13.5 Neighboring gene ephrin-B3b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cajal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    telomerase Cajal body protein 1
    Names
    WD repeat domain 79

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256028.1 → NP_001242957.1  telomerase Cajal body protein 1

      See identical proteins and their annotated locations for NP_001242957.1

      Status: VALIDATED

      Source sequence(s)
      CR388099
      UniProtKB/TrEMBL
      A0A8M1P3C1, E7F3D5
      Related
      ENSDARP00000105980.1, ENSDART00000129161.4
      Conserved Domains (3) summary
      COG2319
      Location:160 → 478
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:166 → 210
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:160 → 474
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      20917964..20940213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172209.5 → XP_005172266.1  telomerase Cajal body protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005172266.1

      UniProtKB/TrEMBL
      A0A8M1P3C1, E7F3D5
      Conserved Domains (3) summary
      COG2319
      Location:160 → 478
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:166 → 210
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:160 → 474
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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