itga6b integrin, alpha 6b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itga6bprovided by ZNC
Official Full Name: integrin, alpha 6bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050320-5
See related: Ensembl:ENSDARG00000069946 AllianceGenome:ZFIN:ZDB-GENE-050320-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fl20e08; wu:fl20e08; zgc:113088; si:dkey-18j14.1
Summary: Predicted to enable integrin binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Is expressed in myotome. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGA6 (integrin subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (31019169..31064706)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (30215223..30260779)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the secreted ligand Dkk3a binds to the membrane receptor Itgalpha6b, which increases the protein level of phosphorylated p38a and activates myf5 promoter activity of zebrafish embryos during myogenesis.
Title: Zebrafish Dkk3a protein regulates the activity of myf5 promoter through interaction with membrane receptor integrin α6b.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fl20e08.x1 (e-PCR)
- UniSTS:202045

fj02b03.y1 (e-PCR)
- UniSTS:198272

fk35c01.x1 (e-PCR)
- UniSTS:200886

fj34g08.x1 (e-PCR)
- UniSTS:199165

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin alpha-6b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013448.1 → NP_001013466.1 integrin alpha-6b precursor

See identical proteins and their annotated locations for NP_001013466.1

Status: PROVISIONAL

Source sequence(s)

BC090458

UniProtKB/TrEMBL

Q5BLF7

Related

ENSDARP00000092986.3, ENSDART00000102210.5

Conserved Domains (2) summary

smart00191
Location:374 → 425

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:468 → 932

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

31019169..31064706

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291986.4 → XP_009290261.1 integrin alpha-6b isoform X1

UniProtKB/TrEMBL

A0A8M3AQ81

Conserved Domains (2) summary

smart00191
Location:374 → 425

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:468 → 932

Integrin_alpha2; Integrin alpha