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    slc6a19b solute carrier family 6 member 19b [ Danio rerio (zebrafish) ]

    Gene ID: 326030, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc6a19bprovided by ZNC
    Official Full Name
    solute carrier family 6 member 19bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4755
    See related
    Ensembl:ENSDARG00000056719 AllianceGenome:ZFIN:ZDB-GENE-030131-4755
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    slc6a19; zgc:66050; wu:fd58f10
    Summary
    Predicted to enable neutral L-amino acid transmembrane transporter activity. Predicted to be involved in neutral amino acid transport and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane and brush border membrane. Is expressed in floor plate; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Hartnup disease. Orthologous to human SLC6A19 (solute carrier family 6 member 19). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc6a19b in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (18974074..18998549)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (19168435..19192910)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene retinoid x receptor, beta b Neighboring gene formin homology 2 domain containing 3b Neighboring gene si:ch211-254p10.2 Neighboring gene uncharacterized LOC137487840

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease. Buglo E, et al. PLoS One, 2020. PMID 32208444, Free PMC Article
    2. Induced Torpor as a Countermeasure for Low Dose Radiation Exposure in a Zebrafish Model. Cahill T, et al. Cells, 2021 Apr 14. PMID 33920039, Free PMC Article
    3. Ustilaginoidin D induces hepatotoxicity and behaviour aberrations in zebrafish larvae. Wang B, et al. Toxicology, 2021 May 30. PMID 33872729
    4. Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Zhao G, et al. Ecotoxicol Environ Saf, 2022 Jun 15. PMID 35526456
    5. Solute carriers (SLCs) identified and characterized from kidney transcriptome of golden mahseer (Tor putitora) (Fam: Cyprinidae). Barat A, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Oct. PMID 27287540

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables neutral L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in neutral amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 6 member 19b
    Names
    solute carrier family 6 (neurotransmitter transporter), member 19
    solute carrier family 6 (neurotransmitter transporter), member 19b
    solute carrier family 6 (neutral amino acid transporter), member 19b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199736.1 → NP_956030.1  solute carrier family 6 member 19b

      See identical proteins and their annotated locations for NP_956030.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059804
      UniProtKB/TrEMBL
      A0A8M1PFT7, Q6PBA3
      Related
      ENSDARP00000073704.5, ENSDART00000079248.6
      Conserved Domains (1) summary
      cd11516
      Location:33 → 613
      SLC6sbd_B0AT1; Na(+)-dependent neutral amino acids transporter, B0AT1; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      18974074..18998549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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