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    oclnb occludin b [ Danio rerio (zebrafish) ]

    Gene ID: 494075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oclnbprovided by ZNC
    Official Full Name
    occludin bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-43
    See related
    Ensembl:ENSDARG00000003091 AllianceGenome:ZFIN:ZDB-GENE-041212-43
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fk83f10; zgc:101820
    Summary
    Predicted to enable thiopurine S-methyltransferase activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including EVL; digestive system; extension; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See oclnb in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (26212626..26220720)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25612420..25620571)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:86811 Neighboring gene MARVEL domain containing 2b Neighboring gene general transcription factor IIH, polypeptide 2 Neighboring gene endoplasmic reticulum aminopeptidase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Chen Z, et al. Front Microbiol, 2020. PMID 32670209, Free PMC Article
    2. Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. Clelland ES, et al. Gen Comp Endocrinol, 2011 Apr 1. PMID 21291886
    3. Dietary nucleotides can directly stimulate the immunity of zebrafish independent of the intestinal microbiota. Guo X, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30590163
    4. Thymol and Carvacrol Affect Hybrid Tilapia through the Combination of Direct Stimulation and an Intestinal Microbiota-Mediated Effect: Insights from a Germ-Free Zebrafish Model. Ran C, et al. J Nutr, 2016 May. PMID 27075912
    5. Intestinal Inflammation Induced by Soybean Meal Ingestion Increases Intestinal Permeability and Neutrophil Turnover Independently of Microbiota in Zebrafish. Solis CJ, et al. Front Immunol, 2020. PMID 32793187, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables thiopurine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bicellular tight junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in bicellular tight junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    occludin b
    NP_001008618.1
    XP_005171901.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008618.1 → NP_001008618.1  occludin b

      See identical proteins and their annotated locations for NP_001008618.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086743
      UniProtKB/TrEMBL
      Q5PRA1
      Related
      ENSDARP00000089285.2, ENSDART00000098514.3
      Conserved Domains (2) summary
      pfam07303
      Location:363 → 458
      Occludin_ELL; Occludin homology domain
      pfam14584
      Location:237 → 266
      DUF4446; Protein of unknown function (DUF4446)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      26212626..26220720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171844.5 → XP_005171901.1  occludin b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BJ48, A2BGQ3
      Related
      ENSDARP00000116151.1, ENSDART00000134432.3
      Conserved Domains (2) summary
      pfam07303
      Location:373 → 468
      Occludin_ELL; Occludin homology domain
      pfam14584
      Location:244 → 273
      DUF4446; Protein of unknown function (DUF4446)
    Nucleotide Protein
    Heading Accession and Version

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