U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    stat1b signal transducer and activator of transcription 1b [ Danio rerio (zebrafish) ]

    Gene ID: 368481, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    stat1bprovided by ZNC
    Official Full Name
    signal transducer and activator of transcription 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-23
    See related
    Ensembl:ENSDARG00000076182 AllianceGenome:ZFIN:ZDB-GENE-030616-23
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    STAT; STAT1; zgc:55503; wu:fi49f02; si:dz73o4.3; si:dz87i4.1; si:by51f19.2; si:by134g18.3; si:dz199m19.1; si:dz199m19.2; si:xx-51f19.2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See stat1b in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (41218893..41247197)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (41417122..41445410)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 75 Neighboring gene uncharacterized LOC137496498 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene signal transducer and activator of transcription 1-alpha/beta-like Neighboring gene signal transducer and activator of transcription 1-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effects of the Essential Oil from Pistacia lentiscus Var. chia on the Lateral Line System and the Gene Expression Profile of Zebrafish (Danio rerio). Serifi I, et al. Molecules, 2019 Oct 30. PMID 31671694, Free PMC Article
    2. Behavioural fever is a synergic signal amplifying the innate immune response. Boltaña S, et al. Proc Biol Sci, 2013 Sep 7. PMID 23843398, Free PMC Article
    3. Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Withers SE, et al. Front Immunol, 2023. PMID 36949945, Free PMC Article
    4. Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos. Hu H, et al. Toxicol Res (Camb), 2016 Mar 1. PMID 30090375, Free PMC Article
    5. Protein Nanoparticles Made of Recombinant Viral Antigens: A Promising Biomaterial for Oral Delivery of Fish Prophylactics. Thwaite R, et al. Front Immunol, 2018. PMID 30072996, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelium development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ISGF3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal transducer and activator of transcription 1b
    Names
    signal transducer and activator of transcription 1, 91kDa

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200091.2 → NP_956385.2  signal transducer and activator of transcription 1b

      See identical proteins and their annotated locations for NP_956385.2

      Status: VALIDATED

      Source sequence(s)
      BX649377
      UniProtKB/TrEMBL
      A0A8M3B5U5, A0A8N7V0P4, B0S789
      Related
      ENSDARP00000000280.9, ENSDART00000000280.11
      Conserved Domains (4) summary
      cd16845
      Location:320 → 477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28921
      Location:138 → 316
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam02865
      Location:2 → 119
      STAT_int; STAT protein, protein interaction domain
      cl15255
      Location:559 → 697
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      41218893..41247197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005167878.5 → XP_005167935.1  signal transducer and activator of transcription 1b isoform X1

      See identical proteins and their annotated locations for XP_005167935.1

      UniProtKB/TrEMBL
      A0A8M3B5U5, A0A8N7V0P4, B0S789
      Related
      ENSDARP00000115509.1, ENSDART00000145674.3
      Conserved Domains (4) summary
      cd16845
      Location:320 → 477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28921
      Location:138 → 316
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam02865
      Location:2 → 119
      STAT_int; STAT protein, protein interaction domain
      cl15255
      Location:559 → 697
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.