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    gdf7 growth differentiation factor 7 [ Danio rerio (zebrafish) ]

    Gene ID: 30642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gdf7provided by ZNC
    Official Full Name
    growth differentiation factor 7provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990714-1
    See related
    Ensembl:ENSDARG00000042784 AllianceGenome:ZFIN:ZDB-GENE-990714-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    bmp12
    Summary
    Predicted to enable cytokine activity. Predicted to be involved in BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; cardiovascular system; liver; muscle; and pleuroperitoneal region. Orthologous to human GDF7 (growth differentiation factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gdf7 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (30833153..30839432, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (30817856..30822766, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene lipid droplet associated hydrolase Neighboring gene uncharacterized LOC137488113 Neighboring gene tripeptidyl peptidase I Neighboring gene YY1 transcription factor a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Rodríguez-Marí A, et al. Gene Expr Patterns, 2005 Jun. PMID 15939378
    2. Absence of an external germinal layer in zebrafish and shark reveals a distinct, anamniote ground plan of cerebellum development. Chaplin N, et al. J Neurosci, 2010 Feb 24. PMID 20181601, Free PMC Article
    3. Genome wide identification, phylogeny, and expression of bone morphogenetic protein genes in tetraploidized common carp (Cyprinus carpio). Chen L, et al. Gene, 2017 Sep 5. PMID 28627438
    4. The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Zhu J, et al. Neurosci Bull, 2020 Sep. PMID 32812127, Free PMC Article
    5. Variation of the genetic expression pattern after exposure to estradiol-17beta and 4-nonylphenol in male zebrafish (Danio rerio). Ruggeri B, et al. Gen Comp Endocrinol, 2008 Aug. PMID 18602103

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    growth differentiation factor 7; growth/differentiation factor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      30833153..30839432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689471.7 → XP_694563.2  growth/differentiation factor 7

      UniProtKB/TrEMBL
      A0A8N7TFB7
      Related
      ENSDARP00000118202.1, ENSDART00000139707.2
      Conserved Domains (2) summary
      smart00204
      Location:324 → 422
      TGFB; Transforming growth factor-beta (TGF-beta) family
      pfam00688
      Location:62 → 250
      TGFb_propeptide; TGF-beta propeptide
    Nucleotide Protein Strain
    Heading Accession and Version

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