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    csnk1g2a casein kinase 1, gamma 2a [ Danio rerio (zebrafish) ]

    Gene ID: 554152, updated on 4-Jan-2025

    Summary

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    Official Symbol
    csnk1g2aprovided by ZNC
    Official Full Name
    casein kinase 1, gamma 2aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6445
    See related
    Ensembl:ENSDARG00000005458 AllianceGenome:ZFIN:ZDB-GENE-030131-6445
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wz8345; csnk1g2; fj97g11; wu:fj97g11; zgc:110719
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within Wnt signaling pathway and protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in nervous system; otic vesicle; pectoral fin; presumptive neural retina; and solid lens vesicle. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See csnk1g2a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23039099..23078751)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (23383387..23423102)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 414 Neighboring gene MAPK interacting serine/threonine kinase 2a Neighboring gene major facilitator superfamily domain containing 12a Neighboring gene NACHT domain containing pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Modulation of bioelectric cues in the evolution of flying fishes. Daane JM, et al. Curr Biol, 2021 Nov 22. PMID 34534441, Free PMC Article
    2. The CK1 gene family: expression patterning in zebrafish development. Albornoz A, et al. Biol Res, 2007. PMID 18064361
    3. A genetic, deletion, physical, and human homology map of the long fin region on zebrafish linkage group 2. Iovine MK, et al. Genomics, 2002 Jun. PMID 12036288
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I; casein kinase I isoform gamma-2
    NP_001019550.1
    XP_005171263.1
    XP_005171264.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024379.1 → NP_001019550.1  casein kinase I isoform gamma-2

      See identical proteins and their annotated locations for NP_001019550.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095384
      UniProtKB/TrEMBL
      A0A0R4IBC9, A0A8N7XJN8, F6NUV2, Q1LWK7, Q503C4
      Related
      ENSDARP00000131332.2, ENSDART00000170669.2
      Conserved Domains (3) summary
      COG0515
      Location:49 → 371
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:49 → 335
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:335 → 377
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23039099..23078751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171206.5 → XP_005171263.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8M2BIW9
      Conserved Domains (3) summary
      COG0515
      Location:49 → 415
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:49 → 335
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:335 → 411
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. XM_005171207.5 → XP_005171264.1  casein kinase I isoform X2

      See identical proteins and their annotated locations for XP_005171264.1

      UniProtKB/TrEMBL
      A0A0R4IBC9, A0A8N7XJN8, F6NUV2, Q1LWK7, Q503C4
      Related
      ENSDARP00000056920.6, ENSDART00000056921.8
      Conserved Domains (3) summary
      COG0515
      Location:49 → 371
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:49 → 335
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:335 → 377
      CK1gamma_C; Casein kinase 1 gamma C terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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