col14a1a collagen, type XIV, alpha 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: col14a1aprovided by ZNC
Official Full Name: collagen, type XIV, alpha 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9889
See related: Ensembl:ENSDARG00000005762 AllianceGenome:ZFIN:ZDB-GENE-030131-9889
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb382; cb542; col14a1; sb:cb382; sb:cb542
Summary: Acts upstream of or within basement membrane assembly. Located in basement membrane. Is expressed in several structures, including integument; median fin fold; nervous system; pectoral fin bud; and pharyngeal arch. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (14707867..15050844)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (14817702..15158601)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Analysis of our CRISPR/Cas9-mediated col14a1a knockout fish showed that collagen XIV-A contributes to timely deposition of laminins. As changes in ECM organization can affect tissue mechanical properties, we analyzed the biomechanics of col14a1a(-/-) regenerative BM using atomic force microscopy (AFM).
Title: Gene profile of zebrafish fin regeneration offers clues to kinetics, organization and biomechanics of basement membrane.
Data indicate that duplicate col14a1 genes col14a1a (id 321298; XM_001922011 on chromosome 16) and col14a1b (id 100331704; XM_003200499 on chromosome 19) are differentially expressed during embryogenesis.
Title: Zebrafish collagen XIV is transiently expressed in epithelia and is required for proper function of certain basement membranes.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within basement membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: collagen alpha-1(XIV) chain

Names: collagen, type XIV, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

14707867..15050844

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009292164.4 → XP_009290439.1 collagen alpha-1(XIV) chain isoform X6

UniProtKB/TrEMBL

A0A8M3AHX6, A0A8M9P888

Conserved Domains (5) summary

pfam01391
Location:1530 → 1619

Collagen; Collagen triple helix repeat (20 copies)

smart00210
Location:1229 → 1424

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:157 → 320

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:626 → 700

fn3; Fibronectin type III domain
XM_009292161.4 → XP_009290436.1 collagen alpha-1(XIV) chain isoform X1

UniProtKB/TrEMBL

A0A8M3AIZ5, A0A8M9P888

Conserved Domains (5) summary

pfam01391
Location:1530 → 1619

Collagen; Collagen triple helix repeat (20 copies)

smart00210
Location:1229 → 1424

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:157 → 320

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:626 → 700

fn3; Fibronectin type III domain
XM_009292162.4 → XP_009290437.1 collagen alpha-1(XIV) chain isoform X3

UniProtKB/TrEMBL

A0A8M3AT92, A0A8M9P888, F1R9Y1

Related

ENSDARP00000017432.6, ENSDART00000027982.9

Conserved Domains (5) summary

pfam01391
Location:1515 → 1604

Collagen; Collagen triple helix repeat (20 copies)

smart00210
Location:1229 → 1424

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:157 → 320

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:626 → 700

fn3; Fibronectin type III domain
XM_068214100.1 → XP_068070201.1 collagen alpha-1(XIV) chain isoform X2

UniProtKB/TrEMBL

A0A8M9P888
XM_009292163.4 → XP_009290438.1 collagen alpha-1(XIV) chain isoform X4

UniProtKB/TrEMBL

A0A8M3AQF5, A0A8M9P888

Conserved Domains (5) summary

pfam01391
Location:1530 → 1619

Collagen; Collagen triple helix repeat (20 copies)

smart00210
Location:1229 → 1424

TSPN; Thrombospondin N-terminal -like domains

cd00063
Location:538 → 617

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd01482
Location:157 → 320

vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...

pfam00041
Location:626 → 700

fn3; Fibronectin type III domain
XM_068214101.1 → XP_068070202.1 collagen alpha-1(XIV) chain isoform X5

UniProtKB/TrEMBL

A0A8M9P888