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    cyp2r1 cytochrome P450, family 2, subfamily R, polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 563369, updated on 5-Jan-2025

    Summary

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    Official Symbol
    cyp2r1provided by ZNC
    Official Full Name
    cytochrome P450, family 2, subfamily R, polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-110114-1
    See related
    Ensembl:ENSDARG00000056587 AllianceGenome:ZFIN:ZDB-GENE-110114-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including cellular response to vitamin D; hematopoietic stem cell proliferation; and vitamin D3 metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver; muscle; ovary; and visceral fat. Used to study vitamin D-dependent rickets type 1B. Human ortholog(s) of this gene implicated in artery disease (multiple); brain infarction; obesity; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See cyp2r1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (27455340..27697234)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (27397459..27426126)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 7b Neighboring gene SRY-box transcription factor 6 Neighboring gene calcitonin/calcitonin-related polypeptide, alpha Neighboring gene phosphodiesterase 3B Neighboring gene COPI coat complex subunit beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Metabolomics and transcriptomics reveal the toxicity of difenoconazole to the early life stages of zebrafish (Danio rerio). Teng M, et al. Aquat Toxicol, 2018 Jan. PMID 29175743
    2. Vitamin D promotes the folate transport and metabolism in zebrafish (Danio rerio). Liang S, et al. Am J Physiol Endocrinol Metab, 2024 Apr 1. PMID 38324257
    3. Action of vitamin D and the receptor, VDRa, in calcium handling in zebrafish (Danio rerio). Lin CH, et al. PLoS One, 2012. PMID 23029160, Free PMC Article
    4. Vitamin D Enhances Neutrophil Generation and Function in Zebrafish (Danio rerio). Liao X, et al. J Innate Immun, 2022. PMID 34564076, Free PMC Article
    5. Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation. Cortes M, et al. Stem Cell Reports, 2015 Oct 13. PMID 26365513, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to vitamin D IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vitamin D3 metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vitamin D 25-hydroxylase
    NP_001373291.1
    XP_068078435.1
    XP_068078436.1
    XP_068078437.1
    XP_068078438.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386362.1 → NP_001373291.1  vitamin D 25-hydroxylase

      Status: VALIDATED

      Source sequence(s)
      AL954331
      UniProtKB/TrEMBL
      A0A8N7TDC5, F6P2A1
      Related
      ENSDARP00000073546.3, ENSDART00000079091.4
      Conserved Domains (1) summary
      cd20661
      Location:67 → 500
      CYP2R1; cytochrome P450 2R1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      27455340..27697234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068222337.1 → XP_068078438.1  vitamin D 25-hydroxylase isoform X2

    2. XM_068222335.1 → XP_068078436.1  vitamin D 25-hydroxylase isoform X1

    3. XM_068222336.1 → XP_068078437.1  vitamin D 25-hydroxylase isoform X2

    4. XM_068222334.1 → XP_068078435.1  vitamin D 25-hydroxylase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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