sycp1 synaptonemal complex protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sycp1provided by ZNC
Official Full Name: synaptonemal complex protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040910-6
See related: Ensembl:ENSDARG00000003904 AllianceGenome:ZFIN:ZDB-GENE-040910-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: isa
Summary: Predicted to enable double-stranded DNA binding activity. Acts upstream of or within male meiosis I and meiotic recombination checkpoint signaling. Predicted to be located in synaptonemal complex. Predicted to be active in central element; male germ cell nucleus; and transverse filament. Is expressed in spermatocyte. Orthologous to human SYCP1 (synaptonemal complex protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (49052735..49061219)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (49054082..49062566)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data from male/female transgenic zebrafish suggest proximal promoter fragment coupled to first exon/first intron of sycp1 gene contains information required for cell-specific expression of sycp1 in spermatocytes/spermatids and early primary oocytes.
Title: A promoter fragment of the sycp1 gene is sufficient to drive transgene expression in male and female meiotic germ cells in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chiasma assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lateral element assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA repair synthesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within meiotic recombination checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within synaptonemal complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in central element	IBA Inferred from Biological aspect of Ancestor more info
is_active_in male germ cell nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptonemal complex	IEA Inferred from Electronic Annotation more info
is_active_in transverse filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: synaptonemal complex protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001118894.1 → NP_001112366.1 synaptonemal complex protein 1

Status: PROVISIONAL

Source sequence(s)

BX005150

UniProtKB/TrEMBL

A0A8M1NI12, F1QYS1

Related

ENSDARP00000006089.5, ENSDART00000011876.8

Conserved Domains (2) summary

pfam05483
Location:84 → 803

SCP-1; Synaptonemal complex protein 1 (SCP-1)

pfam16046
Location:621 → 693

FAM76; FAM76 protein