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    morc2 MORC family CW-type zinc finger 2 [ Danio rerio (zebrafish) ]

    Gene ID: 445488, updated on 9-Dec-2024

    Summary

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    Official Symbol
    morc2provided by ZNC
    Official Full Name
    MORC family CW-type zinc finger 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-40
    See related
    Ensembl:ENSDARG00000028539 AllianceGenome:ZFIN:ZDB-GENE-040822-40
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa19f10; zgc:92010; im:6911946; wu:fa19f10
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be active in nucleus. Is expressed in telencephalon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See morc2 in Genome Data Viewer
    Location:
    chromosome: 25
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (3708087..3745399, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (3582428..3619742, complement)

    Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene inner centromere protein Neighboring gene prion protein, related sequence 3 Neighboring gene zgc:158398 Neighboring gene THO complex 5 Neighboring gene chitinase domain containing 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATPase MORC2
    NP_001003994.1
    XP_005174293.1
    XP_009295992.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003994.1 → NP_001003994.1  ATPase MORC2

      See identical proteins and their annotated locations for NP_001003994.1

      Status: VALIDATED

      Source sequence(s)
      BC080267
      UniProtKB/TrEMBL
      A0A8M2BLV0, Q68EG7
      Related
      ENSDARP00000030104.5, ENSDART00000037973.6
      Conserved Domains (2) summary
      pfam07496
      Location:496 → 542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29 → 161
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007136.7 Reference GRCz11 Primary Assembly

      Range
      3708087..3745399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009297717.4 → XP_009295992.1  ATPase MORC2 isoform X1

      See identical proteins and their annotated locations for XP_009295992.1

      UniProtKB/TrEMBL
      A0A8M2BLV0, Q68EG7
      Conserved Domains (2) summary
      pfam07496
      Location:496 → 542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29 → 161
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

    2. XM_005174236.5 → XP_005174293.1  ATPase MORC2 isoform X1

      See identical proteins and their annotated locations for XP_005174293.1

      UniProtKB/TrEMBL
      A0A8M2BLV0, Q68EG7
      Conserved Domains (2) summary
      pfam07496
      Location:496 → 542
      zf-CW; CW-type Zinc Finger
      pfam13589
      Location:29 → 161
      HATPase_c_3; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    Nucleotide Protein Strain
    Heading Accession and Version

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