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    noc3l NOC3-like DNA replication regulator [ Danio rerio (zebrafish) ]

    Gene ID: 321289, updated on 4-Jan-2025

    Summary

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    Official Symbol
    noc3lprovided by ZNC
    Official Full Name
    NOC3-like DNA replication regulatorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9878
    See related
    Ensembl:ENSDARG00000002487 AllianceGenome:ZFIN:ZDB-GENE-030131-9878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    AD24; cb522; sb:cb522; c10orf117
    Summary
    Predicted to enable chromatin binding activity. Acts upstream of or within muscle organ development and regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including alar plate midbrain region; brain; head; immature eye; and trunk. Orthologous to human NOC3L (NOC3 like DNA replication regulator). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See noc3l in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5399680..5418338, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5364723..5383381, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene leucine-rich, glioma inactivated 1b Neighboring gene solute carrier family 35 member G1 Neighboring gene phospholipase C, epsilon 1 Neighboring gene TBC1 domain family, member 12b Neighboring gene dopamine receptor D6b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Walters KB, et al. Dev Dyn, 2009 Jan. PMID 19097072, Free PMC Article
    2. Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Lu CJ, et al. J Mol Cell Biol, 2019 Jun 1. PMID 30407522, Free PMC Article
    3. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 3 homolog
    Names
    NOC3 protein homolog
    NOC3-like protein
    fad24
    nucleolar complex associated 3 homolog
    nucleolar complex-associated protein 3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002863.1 → NP_001002863.1  nucleolar complex protein 3 homolog

      See identical proteins and their annotated locations for NP_001002863.1

      Status: PROVISIONAL

      Source sequence(s)
      AY648726
      UniProtKB/Swiss-Prot
      Q6DC88, Q6DRN3
      Related
      ENSDARP00000004350.8, ENSDART00000028043.9
      Conserved Domains (3) summary
      COG5117
      Location:121 → 713
      NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
      pfam03914
      Location:555 → 708
      CBF; CBF/Mak21 family
      pfam07540
      Location:214 → 308
      NOC3p; Nucleolar complex-associated protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      5399680..5418338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DRN3.1 GenPept UniProtKB/Swiss-Prot:Q6DRN3

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