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    knl1 kinetochore scaffold 1 [ Danio rerio (zebrafish) ]

    Gene ID: 327226, updated on 9-Dec-2024

    Summary

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    Official Symbol
    knl1provided by ZNC
    Official Full Name
    kinetochore scaffold 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5437
    See related
    Ensembl:ENSDARG00000070239 AllianceGenome:ZFIN:ZDB-GENE-030131-5437
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    casc5; fd18f09; wu:fd18f09; si:dkey-9k8.1
    Summary
    Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Predicted to act upstream of or within cell division. Predicted to be active in nucleus. Used to study primary microcephaly. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly; primary autosomal recessive microcephaly 4; and sarcoma. Orthologous to human KNL1 (kinetochore scaffold 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See knl1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (11086957..11107403, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (10402844..10423280, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene cytokine receptor family member B15 Neighboring gene dystrophin Neighboring gene uncharacterized LOC137495441 Neighboring gene kinetochore localized astrin (SPAG5) binding protein Neighboring gene sidekick cell adhesion molecule 1b Neighboring gene uncharacterized LOC137489975

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Digenic inheritance of human primary microcephaly delineates centrosomal and non-centrosomal pathways. Duerinckx S, et al. Hum Mutat, 2020 Feb. PMID 31696992, Free PMC Article
    2. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within attachment of spindle microtubules to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore scaffold 1
    Names
    cancer susceptibility candidate 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      11086957..11107403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306360.4 → XP_009304635.1  kinetochore scaffold 1 isoform X1

      See identical proteins and their annotated locations for XP_009304635.1

      UniProtKB/TrEMBL
      A0A8M3AY08
      Related
      ENSDARP00000119672.1, ENSDART00000147648.3
      Conserved Domains (1) summary
      COG1196
      Location:1435 → 1618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_001921844.7 → XP_001921879.4  kinetochore scaffold 1 isoform X1

      See identical proteins and their annotated locations for XP_001921879.4

      UniProtKB/TrEMBL
      A0A8M3AY08
      Conserved Domains (1) summary
      COG1196
      Location:1435 → 1618
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394463.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      111111..128285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471115.2 → XP_021326790.1  kinetochore scaffold 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0A9
      Conserved Domains (1) summary
      cl25732
      Location:1287 → 1470
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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