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    pcmtl l-isoaspartyl protein carboxyl methyltransferase, like [ Danio rerio (zebrafish) ]

    Gene ID: 393741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pcmtlprovided by ZNC
    Official Full Name
    l-isoaspartyl protein carboxyl methyltransferase, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1738
    See related
    Ensembl:ENSDARG00000042848 AllianceGenome:ZFIN:ZDB-GENE-040426-1738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73268
    Summary
    Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Acts upstream of or within regulation of calcium-mediated signaling. Predicted to be active in cytoplasm. Is expressed in brain; heart; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pcmtl in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (31214190..31221671, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (31197227..31204720, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene dispatched RND transporter family member 2 Neighboring gene RNA pseudouridine synthase domain containing 2 Neighboring gene coiled-coil domain containing 32 Neighboring gene prolactin releasing hormone 2 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain. Soliman R, et al. Front Genet, 2020. PMID 33552132, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73268

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    l-isoaspartyl protein carboxyl methyltransferase, like
    NP_957062.2
    XP_005158823.1
    XP_005158824.1
    XP_009291400.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200768.2 → NP_957062.2  l-isoaspartyl protein carboxyl methyltransferase, like precursor

      Status: VALIDATED

      Source sequence(s)
      BX649281
      UniProtKB/TrEMBL
      A0A8M3AJ35, F1QL05, Q6PBS7
      Related
      ENSDARP00000118411.1, ENSDART00000132858.3

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      31214190..31221671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158767.5 → XP_005158824.1  l-isoaspartyl protein carboxyl methyltransferase, like isoform X1

      See identical proteins and their annotated locations for XP_005158824.1

      UniProtKB/TrEMBL
      A0A8M2B570, Q6PBS7
      Conserved Domains (2) summary
      pfam01135
      Location:30 → 237
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:34 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_005158766.5 → XP_005158823.1  l-isoaspartyl protein carboxyl methyltransferase, like isoform X1

      See identical proteins and their annotated locations for XP_005158823.1

      UniProtKB/TrEMBL
      A0A8M2B570, Q6PBS7
      Conserved Domains (2) summary
      pfam01135
      Location:30 → 237
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:34 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_009293125.4 → XP_009291400.1  l-isoaspartyl protein carboxyl methyltransferase, like isoform X2

      UniProtKB/TrEMBL
      A0A8M3AJ35, F1QL05, Q6PBS7
      Related
      ENSDARP00000112514.1, ENSDART00000145010.3
      Conserved Domains (2) summary
      pfam01135
      Location:30 → 237
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:34 → 239
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394997.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      981..8462 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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