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    sat1a.2 spermidine/spermine N1-acetyltransferase 1a, duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 431716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sat1a.2provided by ZNC
    Official Full Name
    spermidine/spermine N1-acetyltransferase 1a, duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040704-4
    See related
    Ensembl:ENSDARG00000095908 AllianceGenome:ZFIN:ZDB-GENE-040704-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    SSAT-1; ssat1c; bZ1F1.2; zgc:91957
    Summary
    Enables diamine N-acetyltransferase activity. Predicted to be involved in spermidine acetylation. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sat1a.2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (4366431..4374375)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (4033411..4041340)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 4 Neighboring gene spermidine/spermine N1-acetyltransferase 1a, duplicate 1 Neighboring gene apolipoprotein O, a Neighboring gene expressed sequence EE300746

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Metabolic Alterations in Preneoplastic Development Revealed by Untargeted Metabolomic Analysis. Myllymäki H, et al. Front Cell Dev Biol, 2021. PMID 34414180, Free PMC Article
    2. Duplication and diversification of the spermidine/spermine N1-acetyltransferase 1 genes in zebrafish. Lien YC, et al. PLoS One, 2013. PMID 23326562, Free PMC Article
    3. Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. Chen Y, et al. Biochem J, 2003 Aug 1. PMID 12803540, Free PMC Article
    4. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Le X, et al. Development, 2013 Jun. PMID 23615277, Free PMC Article
    5. Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Ahi EP, et al. Fish Physiol Biochem, 2021 Aug. PMID 34236575, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diamine N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    diamine acetyltransferase 1a.2
    Names
    spermidine/spermine N1-acetyltransferase 1
    NP_001002169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002169.2 → NP_001002169.1  diamine acetyltransferase 1a.2

      See identical proteins and their annotated locations for NP_001002169.1

      Status: VALIDATED

      Source sequence(s)
      CABZ01046677, EH433435
      UniProtKB/TrEMBL
      B2GNJ1, Q6GQM2
      Related
      ENSDARP00000135172.1, ENSDART00000168560.3
      Conserved Domains (2) summary
      COG0456
      Location:1 → 144
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:70 → 144
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      4366431..4374375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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