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    ube2h ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 368425, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ube2hprovided by ZNC
    Official Full Name
    ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-67
    See related
    Ensembl:ENSDARG00000000019 AllianceGenome:ZFIN:ZDB-GENE-030616-67
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc07a05; fi24c01; wu:fc07a05; wu:fi24c01; si:bz3c13.2
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human UBE2H (ubiquitin conjugating enzyme E2 H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See ube2h in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15011341..15059876)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15012586..15061121)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene kelch domain containing 10 Neighboring gene zinc finger, C3HC-type containing 1 Neighboring gene microRNA 183 Neighboring gene microRNA 96

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Shin U, et al. Hum Genomics, 2023 May 19. PMID 37208785, Free PMC Article
    2. Liver transcriptome changes in zebrafish during acclimation to transport-associated stress. Dhanasiri AK, et al. PLoS One, 2013. PMID 23762281, Free PMC Article
    3. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Hoffmann JL, et al. Aquat Toxicol, 2008 Apr 28. PMID 18339436
    4. Comparative analysis of single-cell transcriptomics in human and Zebrafish oocytes. Can H, et al. BMC Genomics, 2020 Jul 8. PMID 32640983, Free PMC Article
    5. Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Hart DO, et al. Nature, 2007 Dec 13. PMID 18046332, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.
      Title: A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 H
    NP_958897.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201489.1 → NP_958897.1  ubiquitin-conjugating enzyme E2 H

      See identical proteins and their annotated locations for NP_958897.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049139
      UniProtKB/TrEMBL
      B2GRU1, Q7ZUF3
      Related
      ENSDARP00000107407.2, ENSDART00000124452.3
      Conserved Domains (2) summary
      COG5078
      Location:1 → 149
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      pfam00179
      Location:31 → 145
      UQ_con; Ubiquitin-conjugating enzyme

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      15011341..15059876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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