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    kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) [ Danio rerio (zebrafish) ]

    Gene ID: 436607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kpna2provided by ZNC
    Official Full Name
    karyopherin alpha 2 (RAG cohort 1, importin alpha 1)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-22
    See related
    Ensembl:ENSDARG00000038066 AllianceGenome:ZFIN:ZDB-GENE-040718-22
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zeh0389; zeh0389r; zgc:86945; hm:zeh0389; zgc:113902; hm:zeh0389r
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in proliferative region. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kpna2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25369980..25377017, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25239432..25246469, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene bromodomain PHD finger transcription factor Neighboring gene transfer RNA serine (anticodon AGA)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. High level of GHR nuclear translocation in skeletal muscle of a hyperplasic transgenic zebrafish. Figueiredo MA, et al. J Mol Endocrinol, 2016 Jan. PMID 26553237
    2. Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay. Chen GD, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16616005
    3. Shedding new light on early sex determination in zebrafish. King AC, et al. Arch Toxicol, 2020 Dec. PMID 32975586, Free PMC Article
    4. Identification of zygotic genes expressed at the midblastula transition in zebrafish. O'Boyle S, et al. Biochem Biophys Res Commun, 2007 Jun 29. PMID 17490614
    5. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC113902

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    importin subunit alpha-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002335.1 → NP_001002335.1  importin subunit alpha-1

      See identical proteins and their annotated locations for NP_001002335.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075790
      UniProtKB/TrEMBL
      Q6DI01
      Related
      ENSDARP00000055489.4, ENSDART00000055490.7
      Conserved Domains (5) summary
      COG5064
      Location:9 → 525
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00020
      Location:110 → 235
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam01749
      Location:9 → 95
      IBB; Importin beta binding domain
      pfam16186
      Location:455 → 505
      Arm_3; Atypical Arm repeat
      sd00043
      Location:112 → 144
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      25369980..25377017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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