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    lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [ Danio rerio (zebrafish) ]

    Gene ID: 557734, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrp8provided by ZNC
    Official Full Name
    low density lipoprotein receptor-related protein 8, apolipoprotein e receptorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050506-134
    See related
    Ensembl:ENSDARG00000070074 AllianceGenome:ZFIN:ZDB-GENE-050506-134
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apoer2; im:7145907; si:dkeyp-63d11.7
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in ventral spinal cord development. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in caveola. Is expressed in several structures, including axial hypoblast; brain; immature eye; neural tube; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lrp8 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (34512330..34807114)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (34528929..34823784)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495933 Neighboring gene uncharacterized LOC137490221 Neighboring gene uncharacterized LOC103908727 Neighboring gene uncharacterized LOC137495982 Neighboring gene uncharacterized LOC137495983 Neighboring gene mesoderm induction early response 1a, transcriptional regulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System. Di Donato V, et al. Neuron, 2018 Mar 7. PMID 29429939
    2. Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period. Imai H, et al. Dev Growth Differ, 2012 Feb. PMID 22364494
    3. An optimized two-finger archive for ZFN-mediated gene targeting. Gupta A, et al. Nat Methods, 2012 Jun. PMID 22543349, Free PMC Article
    4. Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Giousoh A, et al. Gene Expr Patterns, 2015 May-Jul. PMID 25981450
    5. l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b. Zhao G, et al. Chemosphere, 2022 Mar. PMID 34933029

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 8
    Names
    apoer 2
    apolipoprotein E receptor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256393.1 → NP_001243322.1  low-density lipoprotein receptor-related protein 8 precursor

      See identical proteins and their annotated locations for NP_001243322.1

      Status: PROVISIONAL

      Source sequence(s)
      AB690576
      UniProtKB/TrEMBL
      A0A8M1P4G8, G9MDF3
      Related
      ENSDARP00000143584.1, ENSDART00000179450.2
      Conserved Domains (7) summary
      smart00192
      Location:66 → 98
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:511 → 552
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:398 → 428
      EGF_CA; Calcium-binding EGF-like domain
      pfam00057
      Location:240 → 274
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:573 → 613
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam07095
      Location:913 → 980
      IgaA; Intracellular growth attenuator protein IgaA
      pfam14670
      Location:362 → 396
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      34512330..34807114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166257.5 → XP_005166314.1  low-density lipoprotein receptor-related protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BDQ8
      Conserved Domains (7) summary
      smart00192
      Location:66 → 98
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:511 → 552
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:398 → 428
      EGF_CA; Calcium-binding EGF-like domain
      pfam00057
      Location:240 → 274
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:573 → 613
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam07095
      Location:913 → 985
      IgaA; Intracellular growth attenuator protein IgaA
      pfam14670
      Location:362 → 396
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_005166258.5 → XP_005166315.1  low-density lipoprotein receptor-related protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BDN7
      Conserved Domains (7) summary
      smart00192
      Location:66 → 98
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:511 → 552
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:398 → 428
      EGF_CA; Calcium-binding EGF-like domain
      pfam00057
      Location:240 → 274
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:573 → 613
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam07095
      Location:909 → 979
      IgaA; Intracellular growth attenuator protein IgaA
      pfam14670
      Location:362 → 396
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_005166259.5 → XP_005166316.1  low-density lipoprotein receptor-related protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BDS1
      Related
      ENSDARP00000093330.5, ENSDART00000102554.6
      Conserved Domains (6) summary
      smart00192
      Location:66 → 98
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:511 → 552
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:398 → 428
      EGF_CA; Calcium-binding EGF-like domain
      pfam00057
      Location:240 → 274
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:573 → 613
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:362 → 396
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394655.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      386273..555443
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395260.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      162650..331219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_3

    Genomic

    1. NW_018395381.1 Reference GRCz11 ALT_DRER_TU_3

      Range
      19494..291053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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