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    add1 adducin 1 (alpha) [ Danio rerio (zebrafish) ]

    Gene ID: 555511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    add1provided by ZNC
    Official Full Name
    adducin 1 (alpha)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030909-2
    See related
    Ensembl:ENSDARG00000103962 AllianceGenome:ZFIN:ZDB-GENE-030909-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb787; bZ1H20.1; zgc:158352
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in barbed-end actin filament capping; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Predicted to be active in several cellular components, including adherens junction; cytoskeleton; and postsynaptic density. Is expressed in nervous system and pronephric duct. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See add1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (1990280..2067982, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (1964456..2042190, complement)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2C-like Neighboring gene WD repeat domain 7 Neighboring gene si:rp71-1h20.3 Neighboring gene zinc finger protein ZFP2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Epigenomic analysis reveals prevalent contribution of transposable elements to cis-regulatory elements, tissue-specific expression, and alternative promoters in zebrafish. Lee HJ, et al. Genome Res, 2022 Jul. PMID 35649578, Free PMC Article
    2. adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish. Yang S, et al. iScience, 2023 Sep 15. PMID 37636049, Free PMC Article
    3. UVB Irradiation Induced Cell Damage and Early Onset of Junbb Expression in Zebrafish. Chen RY, et al. Animals (Basel), 2020 Jun 25. PMID 32630437, Free PMC Article
    4. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Tang V, et al. J Pediatr Gastroenterol Nutr, 2016 Nov. PMID 27526058, Free PMC Article
    5. Transcriptomic responses of S100 family to bacterial and viral infection in zebrafish. Zhang C, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31546038

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC158352

    General protein information

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    Preferred Names
    alpha-adducin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079958.1 → NP_001073427.1  alpha-adducin

      See identical proteins and their annotated locations for NP_001073427.1

      Status: PROVISIONAL

      Source sequence(s)
      BC128848
      UniProtKB/TrEMBL
      A0A8N7UYH2, A1A5X4
      Related
      ENSDARP00000138089.1, ENSDART00000171131.2
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      1990280..2067982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215878.1 → XP_068071979.1  alpha-adducin isoform X7

    2. XM_005160942.5 → XP_005160999.1  alpha-adducin isoform X3

      UniProtKB/TrEMBL
      A0A8M2B847
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    3. XM_068215879.1 → XP_068071980.1  alpha-adducin isoform X9

    4. XM_068215876.1 → XP_068071977.1  alpha-adducin isoform X2

    5. XM_068215877.1 → XP_068071978.1  alpha-adducin isoform X4

    6. XM_021468841.2 → XP_021324516.1  alpha-adducin isoform X1

      UniProtKB/TrEMBL
      A0A8M9PQG8
      Conserved Domains (2) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
      cl27351
      Location:648 → 815
      E3_binding; e3 binding domain

    7. XM_021468845.2 → XP_021324520.1  alpha-adducin isoform X8

      UniProtKB/TrEMBL
      A0A8M9PTW3
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    8. XM_021468842.2 → XP_021324517.1  alpha-adducin isoform X5

      UniProtKB/TrEMBL
      A0A8M9P3B6
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    9. XM_009295072.4 → XP_009293347.1  alpha-adducin isoform X12

      UniProtKB/TrEMBL
      A0A8M3ATI8
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    10. XM_021468846.2 → XP_021324521.1  alpha-adducin isoform X11

      UniProtKB/TrEMBL
      A0A8M9PQH2
      Related
      ENSDARP00000139374.1, ENSDART00000160144.2
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    11. XM_005160946.5 → XP_005161003.1  alpha-adducin isoform X10

      See identical proteins and their annotated locations for XP_005161003.1

      UniProtKB/TrEMBL
      A0A8M2B7V9
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

    12. XM_021468843.2 → XP_021324518.1  alpha-adducin isoform X6

      UniProtKB/TrEMBL
      A0A8M9P3B6
      Conserved Domains (1) summary
      cl00214
      Location:145 → 390
      Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
    Nucleotide Protein Strain
    Heading Accession and Version

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