tbc1d23 TBC1 domain family, member 23 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tbc1d23provided by ZNC
Official Full Name: TBC1 domain family, member 23provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1253
See related: Ensembl:ENSDARG00000044357 AllianceGenome:ZFIN:ZDB-GENE-040426-1253
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63756
Summary: Involved in embryonic brain development. Acts upstream of or within brain development. Predicted to be located in cytoplasmic vesicle. Predicted to be active in trans-Golgi network. Is expressed in head. Used to study pontocerebellar hypoplasia. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 11. Orthologous to human TBC1D23 (TBC1 domain family member 23). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (28914230..28943056, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (28923672..28952495, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TBC1D23 mediates Golgi-specific LKB1 signaling.
Title: TBC1D23 mediates Golgi-specific LKB1 signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

fi71e02.x1 (e-PCR)
- UniSTS:197898

fk85h07.x1 (e-PCR)
- UniSTS:201637

fc56c01 (e-PCR)
- UniSTS:189383

fc89f04.x1 (e-PCR)
- UniSTS:188371

fi48e05.x1 (e-PCR)
- UniSTS:197622

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in vesicle tethering to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle tethering to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TBC1 domain family member 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200487.1 → NP_956781.1 TBC1 domain family member 23

See identical proteins and their annotated locations for NP_956781.1

Status: PROVISIONAL

Source sequence(s)

BC055235

UniProtKB/Swiss-Prot

Q7SXV1

Related

ENSDARP00000065137.4, ENSDART00000065138.6

Conserved Domains (2) summary

pfam00566
Location:97 → 242

RabGAP-TBC; Rab-GTPase-TBC domain

cl00125
Location:324 → 435

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

28914230..28943056 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165941.5 → XP_005165998.1 TBC1 domain family member 23 isoform X1

UniProtKB/TrEMBL

A0A8M2BD99

Conserved Domains (2) summary

pfam00566
Location:97 → 242

RabGAP-TBC; Rab-GTPase-TBC domain

cl00125
Location:324 → 435

RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...