daw1 dynein assembly factor with WDR repeat domains 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: daw1provided by ZNC
Official Full Name: dynein assembly factor with WDR repeat domains 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-255
See related: Ensembl:ENSDARG00000021462 AllianceGenome:ZFIN:ZDB-GENE-050419-255
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wdr69; zgc:153626; zgc:153780; si:dkey-223n17.5
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in axonemal dynein complex assembly; cilium-dependent cell motility; and determination of left/right symmetry. Acts upstream of or within determination of heart left/right asymmetry; otolith morphogenesis; and regulation of cilium movement. Predicted to be located in ciliary basal body. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; neural tube; and solid lens vesicle. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human DAW1 (dynein assembly factor with WD repeats 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (46382498..46394082)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (46384455..46396062)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities.
Title: Biallelic DAW1 variants cause a motile ciliopathy characterized by laterality defects and subtle ciliary beating abnormalities.
Daw1 regulates the timely onset of cilia motility during development.
Title: Daw1 regulates the timely onset of cilia motility during development.
the zebrafish Oda16 ortholog (Wdr69) is expressed in organs with motile cilia and retains a role in dynein assembly
Title: Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonemal dynein complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium-dependent cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium-dependent cell motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of heart left/right asymmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect intraciliary transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within otolith morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dynein assembly factor with WD repeat domains 1

Names: WD repeat domain 69; WD repeat-containing protein 69; oda16; outer row dynein assembly protein 16 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044352.1 → NP_001037817.1 dynein assembly factor with WD repeat domains 1

Status: PROVISIONAL

Source sequence(s)

BX908751

UniProtKB/TrEMBL

A0A8M1N966, R4GDM4

Related

ENSDARP00000116595.1, ENSDART00000142790.2

Conserved Domains (5) summary

smart00320
Location:376 → 405

WD40; WD40 repeats

COG2319
Location:88 → 405

WD40; WD40 repeat [General function prediction only]

cd00200
Location:84 → 372

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam14933
Location:4 → 81

CEP19; CEP19-like protein

sd00039
Location:137 → 175

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

46382498..46394082

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159260.5 → XP_005159317.1 dynein assembly factor with WD repeat domains 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B5W6, F1RB29

Related

ENSDARP00000017736.9, ENSDART00000024202.9

Conserved Domains (5) summary

smart00320
Location:376 → 415

WD40; WD40 repeats

COG2319
Location:73 → 415

WD40; WD40 repeat [General function prediction only]

cd00200
Location:84 → 372

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam14933
Location:4 → 81

CEP19; CEP19-like protein

sd00039
Location:137 → 175

7WD40; WD40 repeat [structural motif]