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    lrrc59 leucine rich repeat containing 59 [ Danio rerio (zebrafish) ]

    Gene ID: 405868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrrc59provided by ZNC
    Official Full Name
    leucine rich repeat containing 59provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2547
    See related
    Ensembl:ENSDARG00000071426 AllianceGenome:ZFIN:ZDB-GENE-040426-2547
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:85752
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in cytoplasm. Is expressed in several structures, including axis; hatching gland; notochord; otic vesicle; and polster. Orthologous to human LRRC59 (leucine rich repeat containing 59). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrrc59 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (31783145..31787861)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (31668243..31672959)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 3A-like Neighboring gene uncharacterized LOC137490452 Neighboring gene N-acetyltransferase 9 Neighboring gene glutamate receptor, ionotropic, N-methyl D-aspartate 2Cb Neighboring gene microRNA mir-2196

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish. Uszczynska-Ratajczak B, et al. Life Sci Alliance, 2023 Jan. PMID 36283702, Free PMC Article
    2. Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin. Gistelinck C, et al. Sci Rep, 2016 Feb 15. PMID 26876635, Free PMC Article
    3. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC85752

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 59

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212932.1 → NP_998097.1  leucine-rich repeat-containing protein 59

      See identical proteins and their annotated locations for NP_998097.1

      Status: PROVISIONAL

      Source sequence(s)
      BC067603
      UniProtKB/Swiss-Prot
      Q6NWG1
      Related
      ENSDARP00000096361.3, ENSDART00000105584.4
      Conserved Domains (3) summary
      sd00031
      Location:17 → 38
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:84 → 120
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:60 → 118
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      31783145..31787861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394853.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      48667..53383
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NWG1.1 GenPept UniProtKB/Swiss-Prot:Q6NWG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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