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    hdhd2 haloacid dehalogenase-like hydrolase domain containing 2 [ Danio rerio (zebrafish) ]

    Gene ID: 541346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hdhd2provided by ZNC
    Official Full Name
    haloacid dehalogenase-like hydrolase domain containing 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050320-37
    See related
    Ensembl:ENSDARG00000024728 AllianceGenome:ZFIN:ZDB-GENE-050320-37
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110332
    Summary
    Predicted to enable phosphatase activity. Predicted to act upstream of or within dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human HDHD2 (haloacid dehalogenase like hydrolase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See hdhd2 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (14529802..14540574, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (14571685..14582449, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene sigma non-opioid intracellular receptor 1 Neighboring gene katanin p60 subunit A-like 2 Neighboring gene uncharacterized LOC108191465 Neighboring gene immediate early response 3 interacting protein 1 Neighboring gene SKI family transcriptional corepressor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    haloacid dehalogenase-like hydrolase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013473.1 → NP_001013491.1  haloacid dehalogenase-like hydrolase domain-containing protein 2

      See identical proteins and their annotated locations for NP_001013491.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091457
      UniProtKB/Swiss-Prot
      Q5BJJ5
      UniProtKB/TrEMBL
      A0A8M6Z8B0, F1QJW5
      Related
      ENSDARP00000039499.6, ENSDART00000039161.7
      Conserved Domains (3) summary
      TIGR01458
      Location:7 → 257
      HAD-SF-IIA-hyp3; HAD-superfamily subfamily IIA hydrolase, TIGR01458
      pfam13242
      Location:176 → 250
      Hydrolase_like; HAD-hyrolase-like
      pfam13344
      Location:10 → 86
      Hydrolase_6; Haloacid dehalogenase-like hydrolase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      14529802..14540574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357963.3 → XP_017213452.1  haloacid dehalogenase-like hydrolase domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1A7, A0A8M6Z8B0, F1QJW5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJJ5.1 GenPept UniProtKB/Swiss-Prot:Q5BJJ5

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