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    nop2 NOP2 nucleolar protein homolog (yeast) [ Danio rerio (zebrafish) ]

    Gene ID: 321130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nop2provided by ZNC
    Official Full Name
    NOP2 nucleolar protein homolog (yeast)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050309-7
    See related
    Ensembl:ENSDARG00000043304 AllianceGenome:ZFIN:ZDB-GENE-050309-7
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb164; sb:cb164; im:6893299; si:dkey-91i17.1
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in maturation of LSU-rRNA and rRNA base methylation. Predicted to act upstream of or within RNA methylation; RNA processing; and ribosome biogenesis. Predicted to be active in nucleolus. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural tube; and pectoral fin. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nop2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (17234540..17251879, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (17326563..17343896, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase Neighboring gene natriuretic peptide C-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene small nucleolar RNA SNORA29 Neighboring gene general transcription factor IIIC, polypeptide 6, alpha Neighboring gene EMG1 N1-specific pseudouridine methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    28S rRNA (cytosine(4447)-C(5))-methyltransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301359.1 → NP_001288288.1  28S rRNA (cytosine(4447)-C(5))-methyltransferase

      See identical proteins and their annotated locations for NP_001288288.1

      Status: VALIDATED

      Source sequence(s)
      CR936322
      UniProtKB/TrEMBL
      A0A8M1P6F7, F1QWP7
      Related
      ENSDARP00000102247.2, ENSDART00000114272.3
      Conserved Domains (4) summary
      TIGR00446
      Location:310 → 584
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      pfam01189
      Location:375 → 583
      Nol1_Nop2_Fmu; 16S rRNA methyltransferase RsmF
      pfam04086
      Location:555 → 682
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
      pfam17125
      Location:297 → 371
      Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      17234540..17251879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157940.5 → XP_005157997.1  28S rRNA (cytosine(4447)-C(5))-methyltransferase isoform X1

      See identical proteins and their annotated locations for XP_005157997.1

      UniProtKB/TrEMBL
      A0A8M1P6F7, F1QWP7
      Conserved Domains (4) summary
      TIGR00446
      Location:310 → 584
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      pfam01189
      Location:375 → 583
      Nol1_Nop2_Fmu; 16S rRNA methyltransferase RsmF
      pfam04086
      Location:555 → 682
      SRP-alpha_N; Signal recognition particle, alpha subunit, N-terminal
      pfam17125
      Location:297 → 371
      Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF
    Nucleotide Protein Strain
    Heading Accession and Version

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