ulk1a unc-51 like autophagy activating kinase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ulk1aprovided by ZNC
Official Full Name: unc-51 like autophagy activating kinase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080723-31
See related: Ensembl:ENSDARG00000062518 AllianceGenome:ZFIN:ZDB-GENE-080723-31
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:195008
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in autophagy. Predicted to act upstream of or within protein phosphorylation and regulation of autophagy. Is expressed in liver. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (43736072..43775805, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (43742653..43782386, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK1a

Names: unc-51-like kinase 1a

NP_001124103.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130631.1 → NP_001124103.1 serine/threonine-protein kinase ULK1a

See identical proteins and their annotated locations for NP_001124103.1

Status: PROVISIONAL

Source sequence(s)

BC163488

UniProtKB/TrEMBL

B3DJH7

Related

ENSDARP00000084967.3, ENSDART00000090534.6

Conserved Domains (3) summary

smart00220
Location:9 → 271

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14202
Location:6 → 272

STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1

pfam12063
Location:713 → 924

DUF3543; Domain of unknown function (DUF3543)