gtdc1 glycosyltransferase-like domain containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gtdc1provided by ZNC
Official Full Name: glycosyltransferase-like domain containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-050417-8
See related: Ensembl:ENSDARG00000020642 AllianceGenome:ZFIN:ZDB-GENE-050417-8
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: QTMAN; zgc:110568
Summary: Predicted to enable tRNA-queuosine(34) beta-mannosyltransferase activity. Acts upstream of or within central nervous system development. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human GTDC1 (glycosyltransferase like domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (25840720..25912990)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (26029804..26101587)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we utilized a zebrafish model to demonstrate a role for GTDC1 in the development of the central nervous system. Our findings highlight the importance of combining sequencing technologies with the iPSC technology for NDDs modelling that could be applied for personalized medicine.
Title: Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-queuosine(34) beta-mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-queuosine(34) beta-mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tRNA-queuosine alpha-mannosyltransferase

Names: glycosyltransferase-like domain-containing protein 1

NP_001017560.1

EC 2.4.1.110

XP_005167614.1

EC 2.4.1.110

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017560.1 → NP_001017560.1 tRNA-queuosine alpha-mannosyltransferase

See identical proteins and their annotated locations for NP_001017560.1

Status: PROVISIONAL

Source sequence(s)

BC092932

UniProtKB/Swiss-Prot

B0S8J7, Q568B7

UniProtKB/TrEMBL

A0A8M9QAN7

Related

ENSDARP00000016818.5, ENSDART00000024572.7

Conserved Domains (4) summary

cd01635
Location:172 → 354

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

COG0438
Location:255 → 421

RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

pfam12038
Location:2 → 164

DUF3524; Domain of unknown function (DUF3524)

cl10013
Location:303 → 421

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007120.7 Reference GRCz11 Primary Assembly

Range

25840720..25912990

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005167557.5 → XP_005167614.1 tRNA-queuosine alpha-mannosyltransferase isoform X1

UniProtKB/Swiss-Prot

B0S8J7, Q568B7

UniProtKB/TrEMBL

A0A8M6Z8E3, A0A8M9QAN7

Conserved Domains (4) summary

cd01635
Location:172 → 353

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

COG0438
Location:254 → 420

RfaB; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]

pfam12038
Location:2 → 164

DUF3524; Domain of unknown function (DUF3524)

cl10013
Location:302 → 420

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...