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    tpst1 tyrosylprotein sulfotransferase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30677, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tpst1provided by ZNC
    Official Full Name
    tyrosylprotein sulfotransferase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000210-10
    See related
    Ensembl:ENSDARG00000073872 AllianceGenome:ZFIN:ZDB-GENE-000210-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj54g11; wu:fj54g11
    Summary
    Predicted to enable protein-tyrosine sulfotransferase activity. Predicted to be involved in post-translational protein modification. Predicted to act upstream of or within peptidyl-tyrosine sulfation. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alar plate midbrain region; immature eye; integument; nervous system; and periderm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tpst1 in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20652653..20731306, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20716921..20795876, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor, alpha-induced protein 1 (endothelial) Neighboring gene small G protein signaling modulator 2 Neighboring gene aldehyde dehydrogenase 3 family, member A1 Neighboring gene aldehyde dehydrogenase 3 family, member A2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The biology and enzymology of protein tyrosine O-sulfation. Moore KL. J Biol Chem, 2003 Jul 4. PMID 12730193
    2. The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts. Lang I, et al. Int J Mol Sci, 2020 Aug 9. PMID 32784920, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein-tyrosine sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-tyrosine sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-tyrosine sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peptidyl-tyrosine sulfation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-tyrosine sulfotransferase 1
    Names
    TPST-1
    NP_571478.1
    XP_005157559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131403.1 → NP_571478.1  protein-tyrosine sulfotransferase 1

      See identical proteins and their annotated locations for NP_571478.1

      Status: PROVISIONAL

      Source sequence(s)
      BC056786
      UniProtKB/Swiss-Prot
      Q804S9, Q9PTE6
      Related
      ENSDARP00000101352.1, ENSDART00000114464.4
      Conserved Domains (1) summary
      pfam13469
      Location:66 → 253
      Sulfotransfer_3; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20652653..20731306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005157502.5 → XP_005157559.1  protein-tyrosine sulfotransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IQR2, A0A8M2B4A9
      Related
      ENSDARP00000138186.1, ENSDART00000170616.3
      Conserved Domains (1) summary
      pfam13469
      Location:66 → 253
      Sulfotransfer_3; Sulfotransferase family

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394946.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      561589..564840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395322.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      175408..178747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9PTE6.2 GenPept UniProtKB/Swiss-Prot:Q9PTE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.