gstt1a glutathione S-transferase theta 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gstt1aprovided by ZNC
Official Full Name: glutathione S-transferase theta 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031001-13
See related: Ensembl:ENSDARG00000042428 AllianceGenome:ZFIN:ZDB-GENE-031001-13
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb870; gstt1
Summary: Enables glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; eye; intestinal bulb primordium; optic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including GSTT1 (glutathione S-transferase theta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (30787613..30791119, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (30778381..30782029, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: glutathione S-transferase theta-1a

Names: glutathione S-transferase theta 1

NP_001314691.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327762.1 → NP_001314691.1 glutathione S-transferase theta-1a

Status: VALIDATED

Source sequence(s)

EH485183, EH595099, EH606435

UniProtKB/TrEMBL

A0A8M1P3N8, E7EZ94

Related

ENSDARP00000062219.5, ENSDART00000062220.6

Conserved Domains (3) summary

cd03183
Location:91 → 217

GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases

COG0625
Location:3 → 199

GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]

cd03050
Location:3 → 78

GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...