hsp90ab1 heat shock protein 90, alpha (cytosolic), class B member 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hsp90ab1provided by ZNC
Official Full Name: heat shock protein 90, alpha (cytosolic), class B member 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-95
See related: Ensembl:ENSDARG00000029150 AllianceGenome:ZFIN:ZDB-GENE-990415-95
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsp90b; hsp90beta; wu:fa29f01; wu:fa91e11; wu:fd59e11; wu:gcd22h07
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and receptor ligand inhibitor activity. Acts upstream of or within blood vessel development and leukocyte migration. Predicted to be located in dynein axonemal particle; extracellular region; and nucleus. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in cytosol; perinuclear region of cytoplasm; and plasma membrane. Is expressed in eye and head. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to several human genes including HSP90AB1 (heat shock protein 90 alpha family class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (51198445..51211840)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (51385225..51398620)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSP90beta prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
Title: HSP90β prevents aging-related cataract formation through regulation of the charged multivesicular body protein (CHMP4B) and p53.
Data demonstrate that Hsp90alpha and Hsp90beta exhibit similar interactions with co-chaperones, but significantly different behaviors with respect to substrate interactions under stress conditions.
Title: A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fa29f01.s1 (e-PCR)
- UniSTS:202507

hsp90b (e-PCR), detects polymorphism
- UniSTS:205599

Z22041 (e-PCR)
- UniSTS:204705

fd59e11.x1 (e-PCR)
- UniSTS:195760

fj93f02.x1 (e-PCR)
- UniSTS:200371

fa91e11.x1 (e-PCR)
- UniSTS:189636

fa91e11.x1 (e-PCR)
- UniSTS:189637

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor ligand inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of aryl hydrocarbon receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein HSP 90-beta

Names: heat shock protein 90-beta; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha, class B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131310.3 → NP_571385.2 heat shock protein HSP 90-beta

See identical proteins and their annotated locations for NP_571385.2

Status: VALIDATED

Source sequence(s)

BC065359, EH451195

UniProtKB/Swiss-Prot

O57521, Q6P0Y9, Q90475

Related

ENSDARP00000014978.8, ENSDART00000020084.10

Conserved Domains (3) summary

smart00387
Location:34 → 185

HATPase_c; Histidine kinase-like ATPases

PTZ00272
Location:13 → 725

PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional

pfam00183
Location:190 → 715

HSP90; Hsp90 protein