elmo2 engulfment and cell motility 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elmo2provided by ZNC
Official Full Name: engulfment and cell motility 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-140106-84
See related: Ensembl:ENSDARG00000063527 AllianceGenome:ZFIN:ZDB-GENE-140106-84
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable SH3 domain binding activity. Acts upstream of or within glomerulus development and regulation of vasculogenesis. Is expressed in brain; mid cerebral vein; and retinal ganglion cell layer. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (88247..106653, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (82235..103417, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Z1653 (e-PCR)
- UniSTS:67340

z1266 (e-PCR), detects polymorphism
- UniSTS:205121

G39992 (e-PCR)
- UniSTS:54859

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: engulfment and cell motility protein 2

Names: zmp:0000001124

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001200058.1 → NP_001186987.1 engulfment and cell motility protein 2

Status: PROVISIONAL

Source sequence(s)

BC125967, CABZ01085323, LO017730

UniProtKB/TrEMBL

A0A8M1NXH9, A0JMQ5

Related

ENSDARP00000135020.2, ENSDART00000162982.2

Conserved Domains (3) summary

cd13359
Location:530 → 659

PH_ELMO1_CED-12; Engulfment and cell motility protein 1 pleckstrin homology (PH) domain

pfam04727
Location:291 → 460

ELMO_CED12; ELMO/CED-12 family

pfam11841
Location:116 → 265

DUF3361; Domain of unknown function (DUF3361)