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    kcmf1 potassium channel modulatory factor 1 [ Danio rerio (zebrafish) ]

    Gene ID: 393927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kcmf1provided by ZNC
    Official Full Name
    potassium channel modulatory factor 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1383
    See related
    Ensembl:ENSDARG00000067656 AllianceGenome:ZFIN:ZDB-GENE-040426-1383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:64160
    Summary
    Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in negative regulation of HRI-mediated signaling; protein K63-linked ubiquitination; and synaptic signaling. Predicted to be located in late endosome and lysosome. Predicted to be active in plasma membrane. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kcmf1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (55708637..55752147, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (55049473..55082202, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene microRNA 7ba Neighboring gene heterogeneous nuclear ribonucleoprotein K, like Neighboring gene uncharacterized LOC110439833 Neighboring gene neurotrophic tyrosine kinase, receptor, type 2b Neighboring gene calcium/calmodulin-dependent protein kinase IV Neighboring gene WD repeat domain 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC64160

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of HRI-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase KCMF1
    Names
    RING-type E3 ubiquitin transferase KCMF1
    NP_957246.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200952.2 → NP_957246.1  E3 ubiquitin-protein ligase KCMF1

      See identical proteins and their annotated locations for NP_957246.1

      Status: PROVISIONAL

      Source sequence(s)
      AY394941
      UniProtKB/Swiss-Prot
      Q7T321
      Related
      ENSDARP00000088195.4, ENSDART00000097424.6
      Conserved Domains (3) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
      pfam14571
      Location:260 → 330
      Di19_C; Stress-induced protein Di19, C-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      55708637..55752147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_011015302.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7T321.1 GenPept UniProtKB/Swiss-Prot:Q7T321

    Gene LinkOut

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