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    lrp1bb low density lipoprotein receptor-related protein 1Bb [ Danio rerio (zebrafish) ]

    Gene ID: 559293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lrp1bbprovided by ZNC
    Official Full Name
    low density lipoprotein receptor-related protein 1Bbprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-401
    See related
    Ensembl:ENSDARG00000061517 AllianceGenome:ZFIN:ZDB-GENE-070912-401
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-184d2.1
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in animal organ development. Predicted to act upstream of or within endocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); lung disease (multiple); and melanoma. Orthologous to human LRP1B (LDL receptor related protein 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See lrp1bb in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    91
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (36125362..36696218)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (36453497..36886337)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 1b Neighboring gene uncharacterized LOC137496487 Neighboring gene uncharacterized LOC137496488 Neighboring gene uncharacterized LOC137496489 Neighboring gene uncharacterized LOC137496429

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters. Vacca F, et al. J Physiol, 2022 May. PMID 35413133, Free PMC Article
    2. Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development. Thomas-Jinu S, et al. Neuron, 2017 Apr 19. PMID 28392072, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 1B
    Names
    low density lipoprotein receptor related protein-deleted in tumor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      36125362..36696218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021478996.2 → XP_021334671.1  low-density lipoprotein receptor-related protein 1B isoform X1

      UniProtKB/TrEMBL
      A0A8M9QG41
      Conserved Domains (10) summary
      smart00192
      Location:895 → 926
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1295 → 1337
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2936 → 2969
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3444 → 3478
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1879 → 1916
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:1976 → 2016
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2613 → 2642
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:1858 → 1941
      NHL; NHL repeat unit of beta-propeller proteins
      pfam12662
      Location:2916 → 2939
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3245 → 3281
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_021478998.2 → XP_021334673.1  low-density lipoprotein receptor-related protein 1B isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q573
      Conserved Domains (10) summary
      smart00192
      Location:895 → 926
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1295 → 1337
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2936 → 2969
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3444 → 3478
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1879 → 1916
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:1976 → 2016
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2613 → 2642
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:1858 → 1941
      NHL; NHL repeat unit of beta-propeller proteins
      pfam12662
      Location:2916 → 2939
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3245 → 3281
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_021478999.2 → XP_021334674.1  low-density lipoprotein receptor-related protein 1B isoform X4

      UniProtKB/TrEMBL
      A0A8M9QBH9
      Related
      ENSDARP00000116076.1, ENSDART00000139033.2
      Conserved Domains (11) summary
      smart00192
      Location:895 → 926
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1295 → 1337
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2936 → 2969
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:1021 → 1056
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1879 → 1916
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:3442 → 3478
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:1976 → 2016
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2613 → 2642
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:1858 → 1941
      NHL; NHL repeat unit of beta-propeller proteins
      pfam12662
      Location:2916 → 2939
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3245 → 3281
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_021478997.2 → XP_021334672.1  low-density lipoprotein receptor-related protein 1B isoform X2

      UniProtKB/TrEMBL
      A0A8M9PT06
      Conserved Domains (10) summary
      smart00192
      Location:895 → 926
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:1295 → 1337
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:2936 → 2969
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:3444 → 3478
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:1879 → 1916
      NHL; NHL repeat [structural motif]
      pfam00058
      Location:1976 → 2016
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      cl00104
      Location:2613 → 2642
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl18310
      Location:1858 → 1941
      NHL; NHL repeat unit of beta-propeller proteins
      pfam12662
      Location:2916 → 2939
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:3245 → 3281
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RNA

    1. XR_002459542.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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