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    gas2l1 growth arrest-specific 2 like 1 [ Danio rerio (zebrafish) ]

    Gene ID: 572219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gas2l1provided by ZNC
    Official Full Name
    growth arrest-specific 2 like 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070705-38
    See related
    Ensembl:ENSDARG00000078803 AllianceGenome:ZFIN:ZDB-GENE-070705-38
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc51b03; wu:fc51b03; si:ch211-149d1.2
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in cytoskeleton organization; protein localization to microtubule plus-end; and regulation of microtubule polymerization or depolymerization. Predicted to be located in cytoskeleton. Predicted to be active in actin filament and cytoplasm. Predicted to colocalize with microtubule plus-end and stress fiber. Orthologous to human GAS2L1 (growth arrest specific 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gas2l1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24816307..24869659, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24312510..24367180, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene RAS-like, family 10, member A Neighboring gene adaptor related protein complex 1 subunit beta 1 Neighboring gene EWS RNA-binding protein 1b Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin crosslink formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GAS2-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      24816307..24869659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_695912.10 → XP_701004.4  GAS2-like protein 1

      UniProtKB/TrEMBL
      A0A8N7TET5, F1Q515
      Related
      ENSDARP00000099100.3, ENSDART00000112287.4
      Conserved Domains (2) summary
      pfam02187
      Location:230 → 297
      GAS2; Growth-Arrest-Specific Protein 2 Domain
      cl00030
      Location:28 → 154
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    Nucleotide Protein Strain
    Heading Accession and Version

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