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    sumo3a small ubiquitin like modifier 3a [ Danio rerio (zebrafish) ]

    Gene ID: 406398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sumo3aprovided by ZNC
    Official Full Name
    small ubiquitin like modifier 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2133
    See related
    Ensembl:ENSDARG00000028119 AllianceGenome:ZFIN:ZDB-GENE-040426-2133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sumo2; sumo3; sumo3l; fa94a11; zgc:65847; zgc:85643; im:7141764; wu:fa94a11; wu:fb55d09
    Summary
    Predicted to enable protein tag activity and ubiquitin-like protein ligase binding activity. Acts upstream of or within chordate embryonic development and definitive hemopoiesis. Predicted to be located in PML body and cytoplasm. Predicted to be active in nucleus. Is expressed in brain; cranial neural crest cell; digestive system; eye; and pectoral fin bud. Orthologous to human SUMO3 (small ubiquitin like modifier 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sumo3a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (11070260..11073897, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (10834833..10838470, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885660 Neighboring gene uncharacterized LOC137495925 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 6a Neighboring gene PTTG1 interacting protein a Neighboring gene myosin X, like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Yuan H, et al. Cell Res, 2010 Feb. PMID 19704416
    2. Sumoylation of CCAAT/enhancer-binding protein α is implicated in hematopoietic stem/progenitor cell development through regulating runx1 in zebrafish. Yuan H, et al. Sci Rep, 2015 Mar 11. PMID 25757417, Free PMC Article
    3. Sumoylation of CCAAT/enhancer-binding protein α promotes the biased primitive hematopoiesis of zebrafish. Yuan H, et al. Blood, 2011 Jun 30. PMID 21596856
    4. Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI. Mackay EW, et al. Development, 2015 Mar 15. PMID 25758222
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chordate embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within definitive hemopoiesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    small ubiquitin-related modifier 3-like
    Names
    SMT3 suppressor of mif two 3 homolog 2
    SMT3 suppressor of mif two 3 homolog 3, like
    SMT3 suppressor of mif two 3 homolog 3a
    SUMO-3-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213124.2 → NP_998289.1  small ubiquitin-related modifier 3-like

      See identical proteins and their annotated locations for NP_998289.1

      Status: VALIDATED

      Source sequence(s)
      BC058303, BX548046, EH512021
      UniProtKB/Swiss-Prot
      Q6DI05, Q6NV25
      Related
      ENSDARP00000035513.5, ENSDART00000035905.6
      Conserved Domains (1) summary
      cd16115
      Location:16 → 87
      Ubl_SUMO2_3_4; ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier SUMO-2, SUMO-3, SUMO-4, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      11070260..11073897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NV25.1 GenPept UniProtKB/Swiss-Prot:Q6NV25

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