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    gid8a GID complex subunit 8 homolog a (S. cerevisiae) [ Danio rerio (zebrafish) ]

    Gene ID: 393685, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gid8aprovided by ZNC
    Official Full Name
    GID complex subunit 8 homolog a (S. cerevisiae)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1669
    See related
    Ensembl:ENSDARG00000022768 AllianceGenome:ZFIN:ZDB-GENE-040426-1669
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Twa1; gid8; zgc:73100
    Summary
    Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within determination of dorsal identity. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gid8a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (23147228..23151984)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (23126019..23130745)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496343 Neighboring gene si:ch211-196c10.13 Neighboring gene solute carrier family 17 member 9a Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 5aa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Twa1/Gid8 is a β-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Lu Y, et al. Cell Res, 2017 Dec. PMID 28829046, Free PMC Article
    2. Evolution of gene function and regulatory control after whole-genome duplication: comparative analyses in vertebrates. Kassahn KS, et al. Genome Res, 2009 Aug. PMID 19439512, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC73100

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glucose-induced degradation protein 8-A homolog
    Names
    glucose-induced degradation protein 8 homolog
    protein C20orf11 homolog
    two hybrid-associated protein 1 with RanBPM

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200712.1 → NP_957006.1  glucose-induced degradation protein 8-A homolog

      See identical proteins and their annotated locations for NP_957006.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059468
      UniProtKB/Swiss-Prot
      Q6PC55
      Related
      ENSDARP00000035630.4, ENSDART00000030920.6
      Conserved Domains (4) summary
      smart00668
      Location:63 → 119
      CTLH; C-terminal to LisH motif
      smart00757
      Location:116 → 212
      CRA; CT11-RanBPM
      pfam08513
      Location:28 → 53
      LisH; LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      23147228..23151984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017357294.3 → XP_017212783.1  glucose-induced degradation protein 8-A homolog isoform X1

      UniProtKB/Swiss-Prot
      Q6PC55
      Related
      ENSDARP00000145022.1, ENSDART00000180284.1
      Conserved Domains (4) summary
      smart00668
      Location:63 → 119
      CTLH; C-terminal to LisH motif
      smart00757
      Location:116 → 212
      CRA; CT11-RanBPM
      pfam08513
      Location:28 → 53
      LisH; LisH
      pfam10607
      Location:63 → 207
      CLTH; CTLH/CRA C-terminal to LisH motif domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PC55.1 GenPept UniProtKB/Swiss-Prot:Q6PC55

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