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    usp14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) [ Danio rerio (zebrafish) ]

    Gene ID: 335736, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp14provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7676
    See related
    Ensembl:ENSDARG00000025889 AllianceGenome:ZFIN:ZDB-GENE-030131-7676
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55949; wu:fk63d09
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Predicted to be involved in negative regulation of ERAD pathway. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and protein deubiquitination. Predicted to be part of proteasome complex. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See usp14 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2790566..2813259, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (2948667..2971360, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene myosin, light chain 13 Neighboring gene aquaporin 1a (Colton blood group), tandem duplicate 2 Neighboring gene THO complex 1 Neighboring gene Rho-associated, coiled-coil containing protein kinase 1 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. Kuo ZY, et al. J Innate Immun, 2013. PMID 23406717, Free PMC Article
    2. A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect. Hsu CH, et al. Sci Rep, 2015 Jun 3. PMID 26039894, Free PMC Article
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 14
    Names
    ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
    NP_956267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199973.1 → NP_956267.1  ubiquitin carboxyl-terminal hydrolase 14

      See identical proteins and their annotated locations for NP_956267.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044553
      UniProtKB/TrEMBL
      Q803B3
      Related
      ENSDARP00000037906.6, ENSDART00000032540.8
      Conserved Domains (4) summary
      smart00213
      Location:4 → 74
      UBQ; Ubiquitin homologues
      cd02657
      Location:106 → 481
      Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...
      pfam00443
      Location:104 → 480
      UCH; Ubiquitin carboxyl-terminal hydrolase
      cl00155
      Location:5 → 74
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      2790566..2813259 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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