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    prkcea protein kinase C, epsilon a [ Danio rerio (zebrafish) ]

    Gene ID: 100005075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    prkceaprovided by ZNC
    Official Full Name
    protein kinase C, epsilon aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8191
    See related
    Ensembl:ENSDARG00000003008 AllianceGenome:ZFIN:ZDB-GENE-030131-8191
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prkce; fj59b07; wu:fj59b07
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Is expressed in brain; peripheral neurons; and spinal cord. Orthologous to human PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See prkcea in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (25640116..25770231)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (25548628..25678871)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene SIX homeobox 3b Neighboring gene SIX homeobox 2b Neighboring gene endothelial PAS domain protein 1a Neighboring gene glutamate dehydrogenase 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential expression of PKC isoforms in developing zebrafish. Patten SA, et al. Int J Dev Neurosci, 2007 May. PMID 17403595
    2. Proteolysis regulates cardiomyocyte maturation and tissue integration. Fukuda R, et al. Nat Commun, 2017 Feb 17. PMID 28211472, Free PMC Article
    3. Protein kinase C family evolution in jawed vertebrates. Garcia-Concejo A, et al. Dev Biol, 2021 Nov. PMID 34329618
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein kinase C epsilon type
    XP_005156350.1
    XP_005156352.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      25640116..25770231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156293.5 → XP_005156350.1  protein kinase C epsilon type isoform X1

      UniProtKB/TrEMBL
      A0A8M2B2B8, A0A8M9PX29, E7F368
      Related
      ENSDARP00000096385.4, ENSDART00000105608.6
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:415 → 675
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:419 → 739
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:247 → 299
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. XM_005156295.5 → XP_005156352.1  protein kinase C epsilon type isoform X2

      UniProtKB/TrEMBL
      A0A8M2B2A2, A0A8M9Q913
      Conserved Domains (4) summary
      cd04014
      Location:3 → 135
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:414 → 674
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:418 → 738
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:246 → 298
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein Strain
    Heading Accession and Version

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