glra3 glycine receptor, alpha 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: glra3provided by ZNC
Official Full Name: glycine receptor, alpha 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-020402-1
See related: Ensembl:ENSDARG00000011066 AllianceGenome:ZFIN:ZDB-GENE-020402-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: glyRalpha3
Summary: Enables extracellularly glycine-gated ion channel activity. Acts upstream of or within excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in cell projection and plasma membrane. Predicted to be part of chloride channel complex. Is expressed in hindbrain and spinal cord. Orthologous to human GLRA3 (glycine receptor alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (38416268..38538193, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (37698138..37818921, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study showed that Extrasynaptic localization of GlyRalpha3 in the neuron in trigeminal mesencephalic nucleus.
Title: Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables extracellularly glycine-gated ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloride transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycine receptor subunit alpha-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152965.1 → NP_694497.1 glycine receptor subunit alpha-3 precursor

See identical proteins and their annotated locations for NP_694497.1

Status: PROVISIONAL

Source sequence(s)

AJ308516

UniProtKB/TrEMBL

Q90W14

Related

ENSDARP00000012434.7, ENSDART00000009777.9

Conserved Domains (3) summary

TIGR00860
Location:12 → 439

LIC; Cation transporter family protein

pfam02931
Location:47 → 253

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:260 → 436

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

38416268..38538193 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477569.2 → XP_021333244.1 glycine receptor subunit alpha-3 isoform X1

UniProtKB/TrEMBL

A0A8M9Q7Y2

Conserved Domains (1) summary

TIGR00860
Location:13 → 478

LIC; Cation transporter family protein