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    papola poly(A) polymerase alpha [ Danio rerio (zebrafish) ]

    Gene ID: 404041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    papolaprovided by ZNC
    Official Full Name
    poly(A) polymerase alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3507
    See related
    Ensembl:ENSDARG00000009585 AllianceGenome:ZFIN:ZDB-GENE-030131-3507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    papolb; wu:fc43b06; wu:fp01g10; zgc:109706; si:ch211-199l3.6
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to act upstream of or within RNA 3'-end processing and mRNA processing. Predicted to be active in nucleus. Orthologous to several human genes including PAPOLA (poly(A) polymerase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See papola in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (4712776..4738133, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (4669863..4695228, complement)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene BCL11 transcription factor B b Neighboring gene uncharacterized LOC137488610 Neighboring gene adenylate kinase 7a Neighboring gene galactosylceramidase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Galectins in channel catfish, Ictalurus punctatus: Characterization and expression profiling in mucosal tissues. Zhou S, et al. Fish Shellfish Immunol, 2016 Feb. PMID 26767746
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109706

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) polymerase alpha
    Names
    poly(A) polymerase beta (testis specific)
    NP_991321.2
    XP_005160406.1
    XP_009292816.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205758.2 → NP_991321.2  poly(A) polymerase alpha

      Status: PROVISIONAL

      Source sequence(s)
      AL953887
      UniProtKB/TrEMBL
      A0A8M1PF15, Q5SNY2
      Related
      ENSDARP00000053857.5, ENSDART00000053858.7
      Conserved Domains (3) summary
      PTZ00418
      Location:7 → 561
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:365 → 494
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:20 → 362
      PAP_central; Poly(A) polymerase central domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      4712776..4738133 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294541.2 → XP_009292816.1  poly(A) polymerase alpha isoform X2

      UniProtKB/TrEMBL
      A0A8M3AT08
      Conserved Domains (3) summary
      PTZ00418
      Location:7 → 561
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:365 → 494
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:20 → 362
      PAP_central; Poly(A) polymerase central domain

    2. XM_005160349.2 → XP_005160406.1  poly(A) polymerase alpha isoform X1

      UniProtKB/TrEMBL
      A0A8M2B770
      Conserved Domains (3) summary
      PTZ00418
      Location:7 → 561
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:365 → 494
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:20 → 362
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein Strain
    Heading Accession and Version

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