lama5 laminin, alpha 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lama5provided by ZNC
Official Full Name: laminin, alpha 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9823
See related: Ensembl:ENSDARG00000058543 AllianceGenome:ZFIN:ZDB-GENE-030131-9823
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb402; sb:cb402; im:7138247; wu:fb81a10
Summary: Predicted to enable signaling receptor binding activity. Acts upstream of or within several processes, including cell-cell adhesion; fin morphogenesis; and regulation of basement membrane organization. Predicted to be located in basement membrane; extracellular region; and membrane. Is expressed in several structures, including axial mesoderm; nervous system; pectoral fin bud; pericardial region; and pharynx. Human ortholog(s) of this gene implicated in bent bone dysplasia syndrome 2 and familial nephrotic syndrome. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 81

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (9567334..9768746, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (9632364..9833779, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that laminin alpha5, which is concentrated at the distal ends of the fins, organizes the distal cells of the fin fold and pectoral fins in order to promote the morphogenesis of the epidermis.
Title: Laminin alpha5 is essential for the formation of the zebrafish fins.

Submit: New GeneRIF Correction

General gene information

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Markers

fb81a10.x1 (e-PCR)
- UniSTS:191603

fa10g10.s1 (e-PCR)
- UniSTS:188804

fa06e12.s1 (e-PCR)
- UniSTS:202230

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within medial fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of embryonic development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: laminin subunit alpha-5

Names: fra; fransen; unm m538

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039171.1 → NP_001034260.1 laminin subunit alpha-5 precursor

See identical proteins and their annotated locations for NP_001034260.1

Status: PROVISIONAL

Source sequence(s)

DQ232730

UniProtKB/TrEMBL

A0A8M3ANE8, Q2Q1W5

Related

ENSDARP00000045125.6, ENSDART00000045126.7

Conserved Domains (12) summary

smart00180
Location:482 → 529

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00282
Location:2757 → 2896

LamG; Laminin G domain

COG1340
Location:2319 → 2558

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

cd00055
Location:664 → 711

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:3319 → 3465

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

TIGR04527
Location:2158 → 2351

mycoplas_twoTM; two transmembrane protein

pfam00052
Location:1672 → 1796

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1421 → 1469

Laminin_EGF; Laminin EGF domain

pfam00055
Location:51 → 290

Laminin_N; Laminin N-terminal (Domain VI)

pfam06008
Location:2171 → 2429

Laminin_I; Laminin Domain I

pfam06009
Location:2611 → 2741

Laminin_II; Laminin Domain II

cl12013
Location:2383 → 2637

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature