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    usp8 ubiquitin specific peptidase 8 [ Danio rerio (zebrafish) ]

    Gene ID: 565434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    usp8provided by ZNC
    Official Full Name
    ubiquitin specific peptidase 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1949
    See related
    Ensembl:ENSDARG00000063719 AllianceGenome:ZFIN:ZDB-GENE-030131-1949
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb15f07; wu:fb92h07
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Acts upstream of or within regulation of cilium assembly. Predicted to be active in several cellular components, including dendritic spine; midbody; and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See usp8 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (92717..108088)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (92734..107217)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 2a Neighboring gene histidine decarboxylase Neighboring gene GA binding protein transcription factor subunit beta 1 Neighboring gene uncharacterized LOC137488240 Neighboring gene uncharacterized LOC137488239 Neighboring gene transient receptor potential cation channel, subfamily M, member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7. Zhou CJ, et al. Dev Comp Immunol, 2024 Jul. PMID 38636698
    2. EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase. Kasahara K, et al. Nat Commun, 2018 Feb 22. PMID 29472535, Free PMC Article
    3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
    4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
      Title: Fish ubiquitin-specific protease 8 (USP8) inhibits IFN production through autophagy-lysosomal dependent degradation of IRF7.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 8
    XP_009291628.1
    XP_009291629.1
    XP_068070963.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      92717..108088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009293353.4 → XP_009291628.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P169, I3IT16
      Related
      ENSDARP00000126067.1, ENSDART00000151550.1
      Conserved Domains (4) summary
      pfam00443
      Location:735 → 1064
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerisation domain
      cl00125
      Location:175 → 306
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl26464
      Location:316 → 644
      Atrophin-1; Atrophin-1 family

    2. XM_009293354.4 → XP_009291629.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X2

      UniProtKB/TrEMBL
      A0A8M3ARQ7
      Conserved Domains (7) summary
      PHA02682
      Location:311 → 563
      PHA02682; ORF080 virion core protein; Provisional
      cd02674
      Location:735 → 1064
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:733 → 1063
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02993
      Location:336 → 446
      MCPVI; Minor capsid protein VI
      pfam08969
      Location:6 → 115
      USP8_dimer; USP8 dimerization domain
      pfam15336
      Location:618 → 667
      Auts2; Autism susceptibility gene 2 protein
      cl00125
      Location:174 → 305
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    3. XM_068214862.1 → XP_068070963.1  ubiquitin carboxyl-terminal hydrolase 8 isoform X1

      UniProtKB/TrEMBL
      A0A8M9P169, I3IT16
    Nucleotide Protein
    Heading Accession and Version

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