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    uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [ Danio rerio (zebrafish) ]

    Gene ID: 406359, updated on 9-Dec-2024

    Summary

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    Official Symbol
    uqcrfs1provided by ZNC
    Official Full Name
    ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2060
    See related
    Ensembl:ENSDARG00000007745 AllianceGenome:ZFIN:ZDB-GENE-040426-2060
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb78f10; zgc:73109; zgc:85614; wu:fb05d11; wu:fb78f10; wu:fj05e12
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including alar plate midbrain region; axis; hatching gland; optic tectum; and polster. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See uqcrfs1 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (45400759..45403559)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (45128483..45131283)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490300 Neighboring gene V-set and transmembrane domain containing 2B Neighboring gene uncharacterized LOC137496205 Neighboring gene probable RNA-directed DNA polymerase from transposon X-element

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Differential protein profile in zebrafish (Danio rerio) brain under the joint exposure of methyl parathion and cadmium. Ling XP, et al. Environ Sci Pollut Res Int, 2012 Nov. PMID 22767353
    2. asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Cai W, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003559, Free PMC Article
    3. Profiling subcellular localization of nuclear-encoded mitochondrial gene products in zebrafish. Uszczynska-Ratajczak B, et al. Life Sci Alliance, 2023 Jan. PMID 36283702, Free PMC Article
    4. Olfactory imprinting is correlated with changes in gene expression in the olfactory epithelia of the zebrafish. Harden MV, et al. J Neurobiol, 2006 Nov. PMID 17013923
    5. Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes. Johnston IA, et al. J Exp Biol, 2009 Jun. PMID 19482995

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC174806

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit Rieske, mitochondrial
    NP_001096664.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001103194.1 → NP_001096664.1  cytochrome b-c1 complex subunit Rieske, mitochondrial

      See identical proteins and their annotated locations for NP_001096664.1

      Status: PROVISIONAL

      Source sequence(s)
      BC152277
      UniProtKB/TrEMBL
      A0A8M1NE61, A7MCR1
      Related
      ENSDARP00000011707.8, ENSDART00000006868.10
      Conserved Domains (4) summary
      cd03470
      Location:150 → 273
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:109 → 273
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:79 → 144
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
      pfam09165
      Location:2 → 76
      Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      45400759..45403559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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